B5Y9A5 (B5Y9A5_COPPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL ACI17275.1
Ordered Locus Names:	COPRO5265_1033

Organism

Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT) [Complete proteome] [HAMAP]

Taxonomic identifier

309798 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermodesulfobiaceae › Coprothermobacter

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACI17275.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	48 – 55	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B5Y9A5 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 070AB78E13E3140E	FASTA	531	56,693
	10 20 30 40 50 60 MNLSEVVKQL GIKEDYLIPY GGYAYKVDLG ALGEQKGKLV LVTSINPTPA GEGKTTTAIG 70 80 90 100 110 120 LADALAASGK KAIVTLREPS LGPVFGVKGG ATGGGKAHVV PSDKINLHFT GDMHAVTAAH 130 140 150 160 170 180 NLIAAMLGNH IYYKKQPLVD TTKVWWKRAL DMNDRDLRNI VVGLQGNGVP REDGFEITAA 190 200 210 220 230 240 SEIMAIMALS ENFGDFQQRV QRIVLGVTMD GSPLTVADLK AEGAVTALMV DALKPNLVMT 250 260 270 280 290 300 AAGTPAFVHA GPFANIAHGT NSVVATKMAL TYADYVITET GFGSDLGFEK FMDIVAREHS 310 320 330 340 350 360 LIPSAVVLVV SIRAIKHHGQ GQDLDAMDRG FENVLAHIEN IRSFGYDPVV AINVFPDDSE 370 380 390 400 410 420 EEVKRLQELL DEVHVTHAVS TVALDGAQGG MPLAEAVVEK AHKFTANPSY AYELEDSIEQ 430 440 450 460 470 480 KVEKIAKNVY GAKAVEFTSE AKKKLKLVDK FGLSRLPICI AKTQYSLSDD ANLLGRPKDF 490 500 510 520 530 VITIRDIKIS AGAGFIVPLA GSVMTMPGLP KVPQAQEVSV DEKGNVQGLL G

References

[1]	"The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001145 Genomic DNA. Translation: ACI17275.1.
RefSeq	YP_002247352.1. NC_011295.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B5Y9A5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6943710.
GenomeReviews	Gene locus COPRO5265_1033 in contig CP001145_GR.
KEGG	cpo:COPRO5265_1033.
PATRIC	21474892. VBICopPro72829_0961.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5Y9A5_COPPD

Accession

Primary (citable) accession number: B5Y9A5

Entry history

Integrated into UniProtKB/TrEMBL:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)