B5Y8S5 (KITH_COPPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	COPRO5265_0834

Organism

Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT) [Complete proteome] [HAMAP]

Taxonomic identifier

309798 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermodesulfobiaceae › Coprothermobacter › Coprothermobacter proteolyticus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Thymidine kinase HAMAP-Rule MF_00124		PRO_1000095431
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity
	Nucleotide binding	87 – 90	4	ATP By similarity
Sites
	Active site	88	1	Proton acceptor Potential
	Metal binding	144	1	Zinc By similarity
	Metal binding	147	1	Zinc By similarity
	Metal binding	182	1	Zinc By similarity
	Metal binding	185	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5Y8S5 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: E89DD6D1AE8A97C6	FASTA	198	21,861
	10 20 30 40 50 60 MEIITQDGWL EVITGCMFSG KTEELVRRLR RAVIAKKETI AIKPALDTRY DLVAVVSHSG 70 80 90 100 110 120 FSFNAIPVED PKSILGMAKD AEVVGIDEAQ FFTGELVPVI RELLQNKKRV IVAGLDLDFR 130 140 150 160 170 180 GEPFGIMPTL LALADEVTKL HAICSVCGNI ATKTQRLING RPARYDDPTI LVGGLETYEA 190 RCNLHHEVPG KTLTLFKE

References

[1]

"The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT." Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35245 / DSM 5265 / BT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001145 Genomic DNA. Translation: ACI17535.1.
RefSeq	YP_002247172.1. NC_011295.1.
3D structure databases
ProteinModelPortal	B5Y8S5.
ModBase	Search...
Protein-protein interaction databases
STRING	309798.COPRO5265_0834.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACI17535; ACI17535; COPRO5265_0834.
GeneID	6943875.
KEGG	cpo:COPRO5265_0834.
PATRIC	21474498. VBICopPro72829_0783.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076390.
KO	K00857.
OMA	ELICGSM.
Enzyme and pathway databases
BioCyc	CPRO309798:GH7M-827-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_COPPD

Accession

Primary (citable) accession number: B5Y8S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	May 29, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program