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Protein

Phosphopentomutase

Gene

deoB

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotationSAAS annotation

Catalytic activityi

2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotationSAAS annotation
Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mn2+UniRule annotationSAAS annotationNote: Binds 1 or 2 manganese ions.UniRule annotationSAAS annotation
  • Mn2+Note: Binds 1 or 2 manganese ions.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171ManganeseUniRule annotation
Metal bindingi290 – 2901ManganeseUniRule annotation
Metal bindingi326 – 3261ManganeseUniRule annotation
Metal bindingi327 – 3271ManganeseUniRule annotation
Metal bindingi339 – 3391ManganeseUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphopentomutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. cellular metabolic compound salvage Source: InterPro
  3. deoxyribonucleotide catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-783-MONOMER.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotationSAAS annotation (EC:5.4.2.7UniRule annotationSAAS annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:deoBUniRule annotationImported
Ordered Locus Names:COPRO5265_0790Imported
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)Imported
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi309798.COPRO5265_0790.

Structurei

3D structure databases

ProteinModelPortaliB5Y8P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1015.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.
OrthoDBiEOG6R5C7J.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y8P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMKEKVFKR VFLVVIDSFG VGAEPDWAEY GDDPSLNTAL HVIDDRPAPS
60 70 80 90 100
FLWSRGLGYL LKEEPIKQPS VVAKLQELSK GKDSTTGHWE IAGLVMTTPF
110 120 130 140 150
PTYPHGFPPE VMEEFERRIG TKTLGNFPAS GTEIIKQLGE EHMRTGYPIV
160 170 180 190 200
YTSADSVFQI AAHEDVIPVE DLYRMCEIAR ELLTGDHAVA RVIARPFAGK
210 220 230 240 250
PGEFYRTPRR RDFSLPPLGH TILDELVEKG IPVVAVGKIH DLFAGRGISQ
260 270 280 290 300
SVHTENDAEG IKALQELSKT FQQRGLVFAN LVDSDMIYGH RRNVEGYYQN
310 320 330 340 350
IMMIDEGLSL LYDNLTNEDL LIVTADHGND PTFPKHTDHT REYVSFIACS
360 370 380 390
PSFTEGSFLG TLRGYVHIAQ TVIEALGVES ARKWGRTLLK EDV
Length:393
Mass (Da):43,934
Last modified:November 24, 2008 - v1
Checksum:iA46D958A29C535D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI18211.1.
RefSeqiYP_002247137.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI18211; ACI18211; COPRO5265_0790.
KEGGicpo:COPRO5265_0790.
PATRICi21474414. VBICopPro72829_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA. Translation: ACI18211.1.
RefSeqiYP_002247137.1. NC_011295.1.

3D structure databases

ProteinModelPortaliB5Y8P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309798.COPRO5265_0790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI18211; ACI18211; COPRO5265_0790.
KEGGicpo:COPRO5265_0790.
PATRICi21474414. VBICopPro72829_0750.

Phylogenomic databases

eggNOGiCOG1015.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.
OrthoDBiEOG6R5C7J.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciCPRO309798:GH7M-783-MONOMER.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BTImported.

Entry informationi

Entry nameiB5Y8P0_COPPD
AccessioniPrimary (citable) accession number: B5Y8P0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2008
Last sequence update: November 24, 2008
Last modified: March 31, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.