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B5Y8I4

- PNP_COPPD

UniProt

B5Y8I4 - PNP_COPPD

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi487 – 4871MagnesiumUniRule annotation
    Metal bindingi493 – 4931MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciCPRO309798:GH7M-726-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:COPRO5265_0733
    OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
    Taxonomic identifieri309798 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
    ProteomesiUP000001732: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Polyribonucleotide nucleotidyltransferasePRO_0000381878Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309798.COPRO5265_0733.

    Structurei

    3D structure databases

    ProteinModelPortaliB5Y8I4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini553 – 61260KHUniRule annotationAdd
    BLAST
    Domaini622 – 69069S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiISMEDTH.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5Y8I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIERKKIEVT GTVAGKKVIF QSGFLALQAN GAVLARFGDT VALSTVLMSS    50
    EPKLDIDFFP LTVDYEEKSY AVGKIPGGFF KKEGRPTDME ILKARLIDRS 100
    IRPMFPDGMR NEVQVLNMIL AADMENPPDI VALNGTAAAL AVSDIPIPEL 150
    IAGVRVGYID GEYVLNPTFA EMSESQLDLV VAGTRDSIVM IEAGAAEVDK 200
    SILIGGLKFA QEGIRQIIDL IAELKEKVGR PKAEITVVSF PQEQLDFMRN 250
    HEDRFRAALI TPIKQERERA VSELKKALFQ EMLEVFPDLD EAMFNLMFGE 300
    VEKEVVRAYM KSTRKRVDGR AFDEIRPLYA ESSVLPKVHG SGLFIRGQTQ 350
    VLSTVTLGSF SDVQFIDAIG LEEFKRFMHQ YDFPPFSTGE VKPRRGPSRR 400
    EIGHGALVER ALSYLIPSEE VFPYTIRVVS EVLESNGSTS MASTCASSIA 450
    LMSAGVPMAR HVGGIAMGLI EYNDENVVLT DIQGLEDHLG DMDFKVAGTR 500
    EGITALQLDV KVKGISVETL DKAIDQAEVA RSKILDVLYD AIPSPRPLSE 550
    TAPRIVKIEI PVDKIGEVIG PGGRNVKRIT QETGATIDIR EDGVAFVKGL 600
    TDESVNMAKQ QVEMIVKDPE VGEELTARVV RVTPSYAIVE IAPGKTGLLH 650
    VSEVSETRIR SLEDVLSVGQ TIKVWVKEKD GEGRLRFSAK EKKSEAH 697
    Length:697
    Mass (Da):76,623
    Last modified:November 25, 2008 - v1
    Checksum:i07D02A47D5B2CB8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001145 Genomic DNA. Translation: ACI17511.1.
    RefSeqiWP_012544163.1. NC_011295.1.
    YP_002247081.1. NC_011295.1.

    Genome annotation databases

    EnsemblBacteriaiACI17511; ACI17511; COPRO5265_0733.
    GeneIDi6943432.
    KEGGicpo:COPRO5265_0733.
    PATRICi21474298. VBICopPro72829_0693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001145 Genomic DNA. Translation: ACI17511.1 .
    RefSeqi WP_012544163.1. NC_011295.1.
    YP_002247081.1. NC_011295.1.

    3D structure databases

    ProteinModelPortali B5Y8I4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309798.COPRO5265_0733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI17511 ; ACI17511 ; COPRO5265_0733 .
    GeneIDi 6943432.
    KEGGi cpo:COPRO5265_0733.
    PATRICi 21474298. VBICopPro72829_0693.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi ISMEDTH.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci CPRO309798:GH7M-726-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35245 / DSM 5265 / BT.

    Entry informationi

    Entry nameiPNP_COPPD
    AccessioniPrimary (citable) accession number: B5Y8I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3