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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Binding sitei202ATPUniRule annotation1
Binding sitei291ATP; via carbonyl oxygenUniRule annotation1
Binding sitei322ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi348 – 351ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPRO309798:G1GCO-687-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:COPRO5265_0729
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaCoprothermobacterotaCoprothermobacteriaCoprothermobacteralesCoprothermobacteraceaeCoprothermobacter
Proteomesi
  • UP000001732 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000963341 – 393Phosphoglycerate kinaseAdd BLAST393

Proteomic databases

PRIDEiB5Y8I0

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_0729

Structurei

3D structure databases

SMRiB5Y8I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni60 – 63Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B5Y8I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRSIRDAE VRNKRVIVRV DFNVPLDAEG NVVDDFRIRA ALPTIEYLVE
60 70 80 90 100
NGAKVILISH LGRPKGKRDK KYSLVGVAKR LAELLHKEIL FAPDVVGEEV
110 120 130 140 150
ELAVNGLRSG DILLCENVRF HEEEEKNDAE FAKNIASLGE IFVNDAFSAS
160 170 180 190 200
HRAHATVEGI TKFLPSYAGF LMEKEVNYLS MLTENPQRPY YLVLGGAKVS
210 220 230 240 250
DKVALLQNLL PKVDGMVIGG AMVFTFWKAQ GKEIGKSIVE DDLVGFAKEL
260 270 280 290 300
LEQATTQNKE IVLAKDFVVA DENKEHVEIK AISDFGPADI GYDIGPESIK
310 320 330 340 350
EFKNALVKAR TVFWNGPLGL FEDAKFAEGT KQVGAFLADF PGTVVVGGGD
360 370 380 390
TANAVREMEL FEKFAHVSTG GGASLEFLEG KVLPGIAPLV VEG
Length:393
Mass (Da):42,974
Last modified:November 25, 2008 - v1
Checksum:i409A6BFB60BFEF94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA Translation: ACI16869.1
RefSeqiWP_012543521.1, NC_011295.1

Genome annotation databases

EnsemblBacteriaiACI16869; ACI16869; COPRO5265_0729
KEGGicpo:COPRO5265_0729

Similar proteinsi

Entry informationi

Entry nameiPGK_COPPD
AccessioniPrimary (citable) accession number: B5Y8I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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