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Protein

Pantothenate synthetase

Gene

panC

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1
Binding sitei179ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPRO309798:G1GCO-564-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:COPRO5265_0605
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaCoprothermobacterotaCoprothermobacteriaCoprothermobacteralesCoprothermobacteraceaeCoprothermobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000970521 – 287Pantothenate synthetaseAdd BLAST287

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_0605

Structurei

3D structure databases

SMRiB5Y863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175517
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

B5Y863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVRDIKTM REKVAEMKRQ GKSVGLVPTM GYLHEGHLAL IDTARKENDV
60 70 80 90 100
VVVSDFVNPL QFGPNEDYLV YPRDMDRDAQ LCSEHGVDFL FVPTVEEMYP
110 120 130 140 150
KKGNQVDVFV DVKHLDENLC GRFRPGHFRG VVTVVTKLFN IVSPNRAYFG
160 170 180 190 200
MKDIQQLRII EEMVNDLNMN IEIVPVPTVR EPSGLALSSR NTYLSAEERE
210 220 230 240 250
KAASIYKSLL MAKDLILEKG VISTAEVIGT CTRFLSQQGF KVQYFQLVDY
260 270 280
DTLELLPKIE PPQKIIIATA VFLGKVRLID NLVIEVR
Length:287
Mass (Da):32,605
Last modified:November 25, 2008 - v1
Checksum:iA7BC1458CBC21C9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA Translation: ACI18189.1
RefSeqiWP_012544839.1, NC_011295.1

Genome annotation databases

EnsemblBacteriaiACI18189; ACI18189; COPRO5265_0605
KEGGicpo:COPRO5265_0605

Similar proteinsi

Entry informationi

Entry nameiPANC_COPPD
AccessioniPrimary (citable) accession number: B5Y863
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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