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B5Y822

- TRMB_COPPD

UniProt

B5Y822 - TRMB_COPPD

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, COPRO5265_0563
Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281S-adenosyl-L-methionine By similarity
Binding sitei51 – 511S-adenosyl-L-methionine By similarity
Binding sitei75 – 751S-adenosyl-L-methionine By similarity
Binding sitei134 – 1341Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-558-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:COPRO5265_0563
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000387946Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309798.COPRO5265_0563.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni167 – 1704Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Y822-1 [UniParc]FASTAAdd to Basket

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MLIKPQSTSS FPLNWDAIFP EKNPLAVEIG FGNGKFLKTL ETTGTNVVGF    50
EVSLLSVEKA MKVIDHTKTA LLLMDGIWGL RELFSERSVD ALYINFPLPW 100
PHKKHASRRL FTLPKLQIYA SRLVDNAILQ LQTDVKEYAE EAIRNSEESG 150
LFSLADYAVR NEVQVGTKYE QKWVSQGKKI YKVVLRKKRH VSVPNYLDKE 200
VIMPHAIVHD SHGTLKAGTY RTTFGTIKLW EPFSNNQAML LIPAIVSDDD 250
FIGVSLQQRV YISVSPHREG FIVKLDNHAD VFKTENVKSL IWLIANQISN 300
GNIKRINVQP PSKLEYEPA 319
Length:319
Mass (Da):36,203
Last modified:November 25, 2008 - v1
Checksum:iBA9AB3611373D08A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI18005.1.
RefSeqiWP_012544655.1. NC_011295.1.
YP_002246919.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI18005; ACI18005; COPRO5265_0563.
GeneIDi6944137.
KEGGicpo:COPRO5265_0563.
PATRICi21473960. VBICopPro72829_0530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI18005.1 .
RefSeqi WP_012544655.1. NC_011295.1.
YP_002246919.1. NC_011295.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309798.COPRO5265_0563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI18005 ; ACI18005 ; COPRO5265_0563 .
GeneIDi 6944137.
KEGGi cpo:COPRO5265_0563.
PATRICi 21473960. VBICopPro72829_0530.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CPRO309798:GH7M-558-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BT.

Entry informationi

Entry nameiTRMB_COPPD
AccessioniPrimary (citable) accession number: B5Y822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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