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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPRO309798:G1GCO-507-MONOMER
UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:COPRO5265_0545
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
Proteomesi
  • UP000001732 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001253481 – 193Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST193

Interactioni

Protein-protein interaction databases

STRINGi309798.COPRO5265_0545

Structurei

3D structure databases

SMRiB5Y804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W Bacteria
COG1057 LUCA
HOGENOMiHOG000262780
KOiK00969
OMAiIHIGHLI
OrthoDBiPOG091H028Y

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

B5Y804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKPLKSSRT GLLAGVFDPV HIGHLFMAHL AMEAANLDRV WFVPTHIPPH
60 70 80 90 100
KDSAKVPYFH RVNMLEMALK EEPKFVLMEL EREARPTYSY ETILSVKHVL
110 120 130 140 150
GEKPYFILGS DEWEELHNWR RYDLLVKNAI FIVVPRKPIT VARPEAEAIF
160 170 180 190
TDMTPINVSS TYIRQRVAKG KPITYLVPKT VETYIHENHL YYP
Length:193
Mass (Da):22,451
Last modified:November 25, 2008 - v1
Checksum:i193428B8FFC74F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA Translation: ACI17187.1
RefSeqiWP_012543839.1, NC_011295.1

Genome annotation databases

EnsemblBacteriaiACI17187; ACI17187; COPRO5265_0545
KEGGicpo:COPRO5265_0545

Entry informationi

Entry nameiNADD_COPPD
AccessioniPrimary (citable) accession number: B5Y804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health