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B5Y7R0

- SYE_COPPD

UniProt

B5Y7R0 - SYE_COPPD

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Protein
Glutamate--tRNA ligase
Gene
gltX, COPRO5265_0442
Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei252 – 2521ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:COPRO5265_0442
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Glutamate--tRNA ligaseUniRule annotation
PRO_0000367653Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_0442.

Structurei

3D structure databases

ProteinModelPortaliB5Y7R0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi15 – 2511"HIGH" regionUniRule annotation
Add
BLAST
Motifi249 – 2535"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiFFVEEVD.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
1.10.8.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020752. aa-tRNA-synth_I_codon-bd_sub1.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Y7R0-1 [UniParc]FASTAAdd to Basket

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MSVNDSTHIK TRFAPSPTGY LHVGGARTAL FNYLFAKKFG GTFLLRIEDT    50
DPERSKPEYS EQILISMKWL GLDWDEGPYH QSERMHIYQQ YTQKLLEEGK 100
AYRCFCTTEE LEQMREQQRQ QGLPTRYDGR CSRLTQEEIE ERLNKGMPFA 150
VRLKVPQDRG IIAWDDMVKG HIEINSSELD DFILVRSDGT PTYNFAVVID 200
DHTMGVTHVL RGEDHIPNTP KQILIYEALG WETPEFGHVP MILGKDKTKL 250
SKRHGAVGVE AYRDEGFLPE ALFNFLALLG ASYDPDREVY TKQELIDLFD 300
PKKIGLHPAV FDPDKLYYIN REHMKMLPPE ELLDRIRPFA EAKGFQIEPY 350
HLRLIPLLVE RMRTLKDFVE LADYIFTDDF TVDEKAQELL AKDLPLGGLA 400
EQLDATVWDA DHIEAVLRQY AQDKGIKPRD YFPFIRAVIS GKSVGPSLFH 450
LMEAMPKDMV LRRLRKS 467
Length:467
Mass (Da):53,985
Last modified:November 25, 2008 - v1
Checksum:iD9995F970A95DB0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI16900.1.
RefSeqiYP_002246807.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI16900; ACI16900; COPRO5265_0442.
GeneIDi6944687.
KEGGicpo:COPRO5265_0442.
PATRICi21473736. VBICopPro72829_0423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI16900.1 .
RefSeqi YP_002246807.1. NC_011295.1.

3D structure databases

ProteinModelPortali B5Y7R0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309798.COPRO5265_0442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI16900 ; ACI16900 ; COPRO5265_0442 .
GeneIDi 6944687.
KEGGi cpo:COPRO5265_0442.
PATRICi 21473736. VBICopPro72829_0423.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi FFVEEVD.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci CPRO309798:GH7M-437-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
1.10.8.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020752. aa-tRNA-synth_I_codon-bd_sub1.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BT.

Entry informationi

Entry nameiSYE_COPPD
AccessioniPrimary (citable) accession number: B5Y7R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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