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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei252ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPRO309798:G1GCO-411-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:COPRO5265_0442
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaCoprothermobacterotaCoprothermobacteriaCoprothermobacteralesCoprothermobacteraceaeCoprothermobacter
Proteomesi
  • UP000001732 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676531 – 467Glutamate--tRNA ligaseAdd BLAST467

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi309798.COPRO5265_0442

Structurei

3D structure databases

ProteinModelPortaliB5Y7R0
SMRiB5Y7R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi15 – 25"HIGH" regionUniRule annotationAdd BLAST11
Motifi249 – 253"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B5Y7R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNDSTHIK TRFAPSPTGY LHVGGARTAL FNYLFAKKFG GTFLLRIEDT
60 70 80 90 100
DPERSKPEYS EQILISMKWL GLDWDEGPYH QSERMHIYQQ YTQKLLEEGK
110 120 130 140 150
AYRCFCTTEE LEQMREQQRQ QGLPTRYDGR CSRLTQEEIE ERLNKGMPFA
160 170 180 190 200
VRLKVPQDRG IIAWDDMVKG HIEINSSELD DFILVRSDGT PTYNFAVVID
210 220 230 240 250
DHTMGVTHVL RGEDHIPNTP KQILIYEALG WETPEFGHVP MILGKDKTKL
260 270 280 290 300
SKRHGAVGVE AYRDEGFLPE ALFNFLALLG ASYDPDREVY TKQELIDLFD
310 320 330 340 350
PKKIGLHPAV FDPDKLYYIN REHMKMLPPE ELLDRIRPFA EAKGFQIEPY
360 370 380 390 400
HLRLIPLLVE RMRTLKDFVE LADYIFTDDF TVDEKAQELL AKDLPLGGLA
410 420 430 440 450
EQLDATVWDA DHIEAVLRQY AQDKGIKPRD YFPFIRAVIS GKSVGPSLFH
460
LMEAMPKDMV LRRLRKS
Length:467
Mass (Da):53,985
Last modified:November 25, 2008 - v1
Checksum:iD9995F970A95DB0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001145 Genomic DNA Translation: ACI16900.1
RefSeqiWP_012543552.1, NC_011295.1

Genome annotation databases

EnsemblBacteriaiACI16900; ACI16900; COPRO5265_0442
KEGGicpo:COPRO5265_0442

Entry informationi

Entry nameiSYE_COPPD
AccessioniPrimary (citable) accession number: B5Y7R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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