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B5Y6R9

- GCH4_COPPD

UniProt

B5Y6R9 - GCH4_COPPD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei146 – 1461May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCPRO309798:GH7M-94-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:COPRO5265_0095
    OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
    Taxonomic identifieri309798 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
    ProteomesiUP000001732: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271GTP cyclohydrolase FolE2PRO_1000215386Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309798.COPRO5265_0095.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiAKWFFDR.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5Y6R9-1 [UniParc]FASTAAdd to Basket

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    MRDVQSERDP RNVPLDYVGI ENVRLPITVR TKEGGKQPTV GTFSIGVDFP    50
    HSFRGTHMSR FMEVLYQHLE EISQTRLRVT LEDIKERLKA TKAMIEVAFP 100
    FAIKKSTPVT KLETVMYVDA SFKAELNSTR GYVVTSTVTV PVHSLCPCSR 150
    DISEFGAHNQ RVDVTVSWQG DLWIEDVIAL VESSASQPLY PLLKRPDEKY 200
    VTEKAYLNPK FVEDIAKDLF LKLDPLSPCF RIKVVSYESI HPHNAVAIKE 250
    KRAEVSESSV RSNDQEHRDC T 271
    Length:271
    Mass (Da):30,811
    Last modified:November 25, 2008 - v1
    Checksum:iA6F6425ADEA7D22F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001145 Genomic DNA. Translation: ACI18177.1.
    RefSeqiYP_002246466.1. NC_011295.1.

    Genome annotation databases

    EnsemblBacteriaiACI18177; ACI18177; COPRO5265_0095.
    GeneIDi6943542.
    KEGGicpo:COPRO5265_0095.
    PATRICi21473068. VBICopPro72829_0090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001145 Genomic DNA. Translation: ACI18177.1 .
    RefSeqi YP_002246466.1. NC_011295.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309798.COPRO5265_0095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI18177 ; ACI18177 ; COPRO5265_0095 .
    GeneIDi 6943542.
    KEGGi cpo:COPRO5265_0095.
    PATRICi 21473068. VBICopPro72829_0090.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi AKWFFDR.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CPRO309798:GH7M-94-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
      Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35245 / DSM 5265 / BT.

    Entry informationi

    Entry nameiGCH4_COPPD
    AccessioniPrimary (citable) accession number: B5Y6R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3