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B5Y6R9

- GCH4_COPPD

UniProt

B5Y6R9 - GCH4_COPPD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei146 – 1461May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCPRO309798:GH7M-94-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:COPRO5265_0095
OrganismiCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT)
Taxonomic identifieri309798 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter
ProteomesiUP000001732: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271GTP cyclohydrolase FolE2PRO_1000215386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309798.COPRO5265_0095.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiAKWFFDR.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5Y6R9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDVQSERDP RNVPLDYVGI ENVRLPITVR TKEGGKQPTV GTFSIGVDFP
60 70 80 90 100
HSFRGTHMSR FMEVLYQHLE EISQTRLRVT LEDIKERLKA TKAMIEVAFP
110 120 130 140 150
FAIKKSTPVT KLETVMYVDA SFKAELNSTR GYVVTSTVTV PVHSLCPCSR
160 170 180 190 200
DISEFGAHNQ RVDVTVSWQG DLWIEDVIAL VESSASQPLY PLLKRPDEKY
210 220 230 240 250
VTEKAYLNPK FVEDIAKDLF LKLDPLSPCF RIKVVSYESI HPHNAVAIKE
260 270
KRAEVSESSV RSNDQEHRDC T
Length:271
Mass (Da):30,811
Last modified:November 25, 2008 - v1
Checksum:iA6F6425ADEA7D22F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI18177.1.
RefSeqiYP_002246466.1. NC_011295.1.

Genome annotation databases

EnsemblBacteriaiACI18177; ACI18177; COPRO5265_0095.
GeneIDi6943542.
KEGGicpo:COPRO5265_0095.
PATRICi21473068. VBICopPro72829_0090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001145 Genomic DNA. Translation: ACI18177.1 .
RefSeqi YP_002246466.1. NC_011295.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309798.COPRO5265_0095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI18177 ; ACI18177 ; COPRO5265_0095 .
GeneIDi 6943542.
KEGGi cpo:COPRO5265_0095.
PATRICi 21473068. VBICopPro72829_0090.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi AKWFFDR.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CPRO309798:GH7M-94-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
    Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35245 / DSM 5265 / BT.

Entry informationi

Entry nameiGCH4_COPPD
AccessioniPrimary (citable) accession number: B5Y6R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 25, 2008
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3