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B5Y6I0 (THIM_COPPD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:COPRO5265_0005
OrganismCoprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / BT) [Complete proteome] [HAMAP]
Taxonomic identifier309798 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermodesulfobiaceaeCoprothermobacter

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383849

Sites

Binding site481Substrate; via amide nitrogen By similarity
Binding site1241ATP By similarity
Binding site1691ATP By similarity
Binding site1961Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B5Y6I0 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: AAE98C7F131BDB35

FASTA27028,532
        10         20         30         40         50         60 
MVSQPSVNIK EILEQVVSTK PLVYHMTNMV AMAEQAHLTL AIGASPVMSL SSEEAAEMVN 

        70         80         90        100        110        120 
IANAVLINIG TPSKEANEAM LSAAHTAKRL GKPAILDPVG YGATKLRINL VERLLETGAF 

       130        140        150        160        170        180 
SLVKGNGGEI SLLAGERAEV RGVDSVGSPP AAIAAKTVAQ KYNCIAAATG PDDYVSDGER 

       190        200        210        220        230        240 
VYVLRSGHEW LTRISGSGCW AGTLMAACLS VTEPLPAAMS ALSLMGAASQ IAAEQSDGPG 

       250        260        270 
TFRIRMFDVM YQITQNPHAF SFPQWELMEV 

« Hide

References

[1]"The complete genome sequence of Coprothermobacter proteolyticus strain ATCC 5245 / DSM 5265 / BT."
Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35245 / DSM 5265 / BT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001145 Genomic DNA. Translation: ACI16808.1.
RefSeqYP_002246377.1. NC_011295.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309798.COPRO5265_0005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI16808; ACI16808; COPRO5265_0005.
GeneID6944332.
KEGGcpo:COPRO5265_0005.
PATRIC21472898. VBICopPro72829_0005.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycCPRO309798:GH7M-5-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_COPPD
AccessionPrimary (citable) accession number: B5Y6I0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways