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B5Y2Y3

- MSRA_KLEP3

UniProt

B5Y2Y3 - MSRA_KLEP3

Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521UniRule annotation

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-5050-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
    Short name:
    Protein-methionine-S-oxide reductaseUniRule annotation
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductaseUniRule annotation
    Short name:
    Peptide Met(O) reductaseUniRule annotation
    Gene namesi
    Name:msrAUniRule annotation
    Ordered Locus Names:KPK_5049
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Peptide methionine sulfoxide reductase MsrAPRO_1000145412Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi507522.KPK_5049.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263862.
    KOiK07304.
    OMAiYAGGQTP.
    OrthoDBiEOG6091JX.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5Y2Y3-1 [UniParc]FASTAAdd to Basket

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    MSLFDKTHLV AQADALPGRN TPMPVATLHA VNGHSMTNVP AGMEVALFAM    50
    GCFWGVERLF WQLPGVYSTA AGYTGGYTPN PTYREVCSGQ TGHAEAVRVV 100
    YDPQVISYEQ LLQVFWENHD PAQGMRQGND HGTQYRSAIY PLTPEQTAAA 150
    KASLARFQAA MNDAHDTRHI TTEIATAKPF YYAEDDHQQY LYKNPHGYCG 200
    IGGIGVCLPP Q 211
    Length:211
    Mass (Da):23,180
    Last modified:November 25, 2008 - v1
    Checksum:iA7870D428A18CB0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06650.1.
    RefSeqiYP_002240824.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI06650; ACI06650; KPK_5049.
    GeneIDi6940038.
    KEGGikpe:KPK_5049.
    PATRICi20443209. VBIKlePne121904_4937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06650.1 .
    RefSeqi YP_002240824.1. NC_011283.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_5049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI06650 ; ACI06650 ; KPK_5049 .
    GeneIDi 6940038.
    KEGGi kpe:KPK_5049.
    PATRICi 20443209. VBIKlePne121904_4937.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263862.
    KOi K07304.
    OMAi YAGGQTP.
    OrthoDBi EOG6091JX.

    Enzyme and pathway databases

    BioCyci KPNE507522:GI0B-5050-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiMSRA_KLEP3
    AccessioniPrimary (citable) accession number: B5Y2Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3