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B5Y2Y3

- MSRA_KLEP3

UniProt

B5Y2Y3 - MSRA_KLEP3

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Protein

Peptide methionine sulfoxide reductase MsrA

Gene
msrA, KPK_5049
Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521 By similarity

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-5050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Gene namesi
Name:msrA
Ordered Locus Names:KPK_5049
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Peptide methionine sulfoxide reductase MsrAUniRule annotationPRO_1000145412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi507522.KPK_5049.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263862.
KOiK07304.
OMAiYAGGQTP.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y2Y3-1 [UniParc]FASTAAdd to Basket

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MSLFDKTHLV AQADALPGRN TPMPVATLHA VNGHSMTNVP AGMEVALFAM    50
GCFWGVERLF WQLPGVYSTA AGYTGGYTPN PTYREVCSGQ TGHAEAVRVV 100
YDPQVISYEQ LLQVFWENHD PAQGMRQGND HGTQYRSAIY PLTPEQTAAA 150
KASLARFQAA MNDAHDTRHI TTEIATAKPF YYAEDDHQQY LYKNPHGYCG 200
IGGIGVCLPP Q 211
Length:211
Mass (Da):23,180
Last modified:November 25, 2008 - v1
Checksum:iA7870D428A18CB0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI06650.1.
RefSeqiYP_002240824.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI06650; ACI06650; KPK_5049.
GeneIDi6940038.
KEGGikpe:KPK_5049.
PATRICi20443209. VBIKlePne121904_4937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI06650.1 .
RefSeqi YP_002240824.1. NC_011283.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 507522.KPK_5049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI06650 ; ACI06650 ; KPK_5049 .
GeneIDi 6940038.
KEGGi kpe:KPK_5049.
PATRICi 20443209. VBIKlePne121904_4937.

Phylogenomic databases

eggNOGi COG0225.
HOGENOMi HOG000263862.
KOi K07304.
OMAi YAGGQTP.
OrthoDBi EOG6091JX.

Enzyme and pathway databases

BioCyci KPNE507522:GI0B-5050-MONOMER.

Family and domain databases

Gene3Di 3.30.1060.10. 1 hit.
HAMAPi MF_01401. MsrA.
InterProi IPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view ]
PANTHERi PTHR10173. PTHR10173. 1 hit.
Pfami PF01625. PMSR. 1 hit.
[Graphical view ]
SUPFAMi SSF55068. SSF55068. 1 hit.
TIGRFAMsi TIGR00401. msrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiMSRA_KLEP3
AccessioniPrimary (citable) accession number: B5Y2Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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