B5Y2S5 (IOLG_KLEP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	KPK_4990

Organism

Klebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP]

Taxonomic identifier

507522 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_1000187318

Sequences

	Sequence		Length	Mass (Da)
	B5Y2S5 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 981CE0FBBCD0C894	FASTA	337	36,768
	10 20 30 40 50 60 MSLKLGVIGA GAIGKEHIRR CTQVLQGATV VAVSDINADN ARAAVALPGV QAEVYADGHD 70 80 90 100 110 120 VINASDVDAI LVTSWDPTHE EYTLAAIAAG KPVFCEKPLA MSAEGCRRIV DAEMKAGRRL 130 140 150 160 170 180 VQVGFMRPYD EGYLALKKVI DDGDIGAPLM LRCAHRNQSV GENYTTDMAI TNTLIHELDV 190 200 210 220 230 240 LRWLLNDDYR SVQVRFPRST SHTHARLKDP QIVSFETKKG TLIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIARL PEPSAVQMRK SASLSTAILT DWKDRFIKAY DVELQAFIND VKAGQLHGPS 310 320 330 AWDGYAASVA ADACIKAQGT SEPVEVTLPE CPAFYKR

References

[1]

"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice." Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A. PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 342.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000964 Genomic DNA. Translation: ACI11005.1.
RefSeq	YP_002240766.1. NC_011283.1.
3D structure databases
ProteinModelPortal	B5Y2S5.
ModBase	Search...
Protein-protein interaction databases
STRING	B5Y2S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6939921.
GenomeReviews	Gene locus KPK_4990 in contig CP000964_GR.
KEGG	kpe:KPK_4990.
PATRIC	20443095. VBIKlePne121904_4880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK2792832.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_KLEP3

Accession

Primary (citable) accession number: B5Y2S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program