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Protein

Inosose dehydratase

Gene

iolE

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-4989-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:KPK_4988
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Inosose dehydratasePRO_1000187327Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB5Y2S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE. 1 hit.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y2S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKDNVKLAI APIGWTNDDM PELGSENTFQ QIVSEMALAG FTGSEVGSKY
60 70 80 90 100
PRDPAVLKPM LDIRGIQICN AWFSTFFANG QREKTIDEFV NHMNFLHAMG
110 120 130 140 150
ANVIGCSEQS GSIQGLDKPI LGDAKPCFSE EEWQRVAEGY NTLGRLAAEK
160 170 180 190 200
GMQVCLHHHM GTGIQTTAEI DKFMSLVDER VFLLFDTGHA WYSEGGEAPM
210 220 230 240 250
LAILKKYLPR INHVHLKDVR PPVIDQVRRD GLSFLDGVKK GTFTVPGDGV
260 270 280 290
IDFRPVFKLL DDFGYKGWMV VEAEQDPALA NPFEYAVKAR KYIRETAGI
Length:299
Mass (Da):33,316
Last modified:November 25, 2008 - v1
Checksum:iBE4498ECD74F547C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11772.1.
RefSeqiWP_012543072.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI11772; ACI11772; KPK_4988.
KEGGikpe:KPK_4988.
PATRICi20443091. VBIKlePne121904_4878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11772.1.
RefSeqiWP_012543072.1. NC_011283.1.

3D structure databases

ProteinModelPortaliB5Y2S3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI11772; ACI11772; KPK_4988.
KEGGikpe:KPK_4988.
PATRICi20443091. VBIKlePne121904_4878.

Phylogenomic databases

HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-4989-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE. 1 hit.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLE_KLEP3
AccessioniPrimary (citable) accession number: B5Y2S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.