B5Y1W7 (B5Y1W7_KLEP3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	KPK_4667

Organism

Klebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP] EMBL ACI11428.1

Taxonomic identifier

507522 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	133 – 137	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	73	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B5Y1W7 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 57ED9564387DBC68	FASTA	287	31,485
	10 20 30 40 50 60 MAERITGHTE LIGLIATPIR HSMSPTMHNE AFAHLGLDYV YLAFEVGNQE LKDVVQGFRA 70 80 90 100 110 120 MKLRGFNVSM PNKTEICQYL DKLSPAAQLV GAVNTVVNDD GVLTGHITDG TGYMRALSEA 130 140 150 160 170 180 GIDIIGKKMT VLGAGGAATA LCVQAALDGV KAISIFNRRD KFFANAEETV AKIRNNTNCE 190 200 210 220 230 240 IHLFDLDDHD KLRAEIDSSV ILTNATGVGM KPFEGQMLLP NDSFLRPDLI VSDVVYNPRK 250 260 270 280 THLLEVAEKK GCRTLNGLGM MLWQGARAFE IWTGKQMPVD YIKSILF

References

[1]

"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice." Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A. PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000964 Genomic DNA. Translation: ACI11428.1.
RefSeq	YP_002240458.1. NC_011283.1.
3D structure databases
ProteinModelPortal	B5Y1W7.
ModBase	Search...
Protein-protein interaction databases
STRING	B5Y1W7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6940012.
GenomeReviews	Gene locus KPK_4667 in contig CP000964_GR.
KEGG	kpe:KPK_4667.
PATRIC	20442483. VBIKlePne121904_4583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	SIYIDAT.
ProtClustDB	PRK00258.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5Y1W7_KLEP3

Accession

Primary (citable) accession number: B5Y1W7

Entry history

Integrated into UniProtKB/TrEMBL:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)