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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:KPK_4328
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000947861 – 354S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST354

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5Y0Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

B5Y0Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTDFAFEL PESLIAHYPM PERSSCRLLS LDGPTGALTH GTFTDILDKL
60 70 80 90 100
NPGDLLVFNN TRVIPARLFG RKASGGKIEV LVERMLDDKR ILAHIRASKA
110 120 130 140 150
PKPGAELLLG DDESIKATML ARHGALFEVE FNDERPVLEI LNGIGHMPLP
160 170 180 190 200
PYIDRPDEDA DRELYQTVYG TRPGAVAAPT AGLHFDEPLL DKLRAKGVEM
210 220 230 240 250
AFVTLHVGAG TFQPVRVDSI EEHTMHSEYA EVPQEVVDAV LAAKARGNRV
260 270 280 290 300
IAVGTTSVRS LESAAQAAKD ALIAPFFDDT QIFIYPGYQY QVIDALVTNF
310 320 330 340 350
HLPESTLIML VSAFAGYQHT MNAYKVAVEQ KYRFFSYGDA MFITYNPQAI

SERP
Length:354
Mass (Da):39,134
Last modified:November 25, 2008 - v1
Checksum:iF8FE6B0E3FF7B7FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI08618.1.
RefSeqiWP_002890390.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI08618; ACI08618; KPK_4328.
KEGGikpe:KPK_4328.
PATRICi20441866. VBIKlePne121904_4283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI08618.1.
RefSeqiWP_002890390.1. NC_011283.1.

3D structure databases

ProteinModelPortaliB5Y0Y7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI08618; ACI08618; KPK_4328.
KEGGikpe:KPK_4328.
PATRICi20441866. VBIKlePne121904_4283.

Phylogenomic databases

HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.

Enzyme and pathway databases

UniPathwayiUPA00392.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEA_KLEP3
AccessioniPrimary (citable) accession number: B5Y0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.