B5XZA0 (6PGL_KLEP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31

Gene names

Name:	pgl
Ordered Locus Names:	KPK_3798

Organism

Klebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP]

Taxonomic identifier

507522 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605
Sequence similarities	Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	6-phosphogluconolactonase HAMAP MF_01605		PRO_1000148160

Sequences

	Sequence		Length	Mass (Da)
	B5XZA0 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: B5F75E9B1D4C0945	FASTA	331	36,200
	10 20 30 40 50 60 MKQTVYTASP ESQQIHVWSL EADGKLTLVQ VVDAPGQVQP MVVSPNKEYL YVGVRPEFRV 70 80 90 100 110 120 LAYRITPDNG ALTFAGEAAL PGSPTHISTD HHGRFVFSAS YNQGCVSVTP LQDGLPGETV 130 140 150 160 170 180 TVVEGLEGCH SANISPDNRT LWVPALKQDR ICLFTLSEDG FLSAQEPAEV TTVDGAGPRH 190 200 210 220 230 240 MVFHPNQQYG YCVNELNSSV DVWELKDPNG NIECVQTLDM MPQDFTGVRW AADIHITPDG 250 260 270 280 290 300 RHLYACDRTA SIITVFSVSE DGSVLAVEGY QPTETQPRGF NLDHSGKYLI AAGQKSHHIA 310 320 330 VYEIEGEQGL LHEKGRYAVG QGPMWVVVNA H

References

[1]

"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice." Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A. PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 342.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000964 Genomic DNA. Translation: ACI10293.1.
RefSeq	YP_002239617.1. NC_011283.1.
3D structure databases
ProteinModelPortal	B5XZA0.
ModBase	Search...
Protein-protein interaction databases
STRING	B5XZA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6937870.
GenomeReviews	Gene locus KPK_3798 in contig CP000964_GR.
KEGG	kpe:KPK_3798.
PATRIC	20440879. VBIKlePne121904_3807.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG741123.
OMA	FLISAGQ.
ProtClustDB	PRK11028.
Family and domain databases
HAMAP	MF_01605. 6P-gluconolactonase. [Tree]
InterPro	IPR022528. 6-phosphogluconolactonase_YbhE. IPR019405. Lactonase_7-beta_prop. IPR011045. N2O_reductase_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K07404.
Pfam	PF10282. Lactonase. 1 hit. [Graphical view]
SUPFAM	SSF50974. N2O_reductase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_KLEP3

Accession

Primary (citable) accession number: B5XZA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program