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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:KPK_3798
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001481601 – 3316-phosphogluconolactonaseAdd BLAST331

Proteomic databases

PRIDEiB5XZA0

Structurei

3D structure databases

ProteinModelPortaliB5XZA0
SMRiB5XZA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 2 hits

Sequencei

Sequence statusi: Complete.

B5XZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTVYTASP ESQQIHVWSL EADGKLTLVQ VVDAPGQVQP MVVSPNKEYL
60 70 80 90 100
YVGVRPEFRV LAYRITPDNG ALTFAGEAAL PGSPTHISTD HHGRFVFSAS
110 120 130 140 150
YNQGCVSVTP LQDGLPGETV TVVEGLEGCH SANISPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTLSEDG FLSAQEPAEV TTVDGAGPRH MVFHPNQQYG YCVNELNSSV
210 220 230 240 250
DVWELKDPNG NIECVQTLDM MPQDFTGVRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SIITVFSVSE DGSVLAVEGY QPTETQPRGF NLDHSGKYLI AAGQKSHHIA
310 320 330
VYEIEGEQGL LHEKGRYAVG QGPMWVVVNA H
Length:331
Mass (Da):36,200
Last modified:November 25, 2008 - v1
Checksum:iB5F75E9B1D4C0945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA Translation: ACI10293.1
RefSeqiWP_012542415.1, NC_011283.1

Genome annotation databases

EnsemblBacteriaiACI10293; ACI10293; KPK_3798
KEGGikpe:KPK_3798

Similar proteinsi

Entry informationi

Entry namei6PGL_KLEP3
AccessioniPrimary (citable) accession number: B5XZA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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