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Protein

Urocanate hydratase

Gene

hutU

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotation

Cofactori

NAD(+)UniRule annotationNote: Binds 1 NAD(+) per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-3779-MONOMER.
UniPathwayiUPA00379; UER00550.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocanate hydrataseUniRule annotation (EC:4.2.1.49UniRule annotation)
Short name:
UrocanaseUniRule annotation
Alternative name(s):
Imidazolonepropionate hydrolaseUniRule annotation
Gene namesi
Name:hutUUniRule annotation
Ordered Locus Names:KPK_3778
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Urocanate hydratasePRO_1000129565Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi507522.KPK_3778.

Family & Domainsi

Sequence similaritiesi

Belongs to the urocanase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2987.
HOGENOMiHOG000237606.
KOiK01712.
OMAiHEWAPRV.
OrthoDBiEOG62K1TR.

Family and domain databases

HAMAPiMF_00577. HutU.
InterProiIPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view]
PfamiPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMiSSF111326. SSF111326. 1 hit.
TIGRFAMsiTIGR01228. hutU. 1 hit.
PROSITEiPS01233. UROCANASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XZ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSKYRQLD VRAPRGTTLT ARSWLTEAPL RMLMNNLDPD VAENPHELVV
60 70 80 90 100
YGGIGRAARN WECYDAIVKA LKNLESDETL LVQSGKPVGV FKTHENSPRV
110 120 130 140 150
LIANSNLVPH WATWEHFNEL DAKGLAMYGQ MTAGSWIYIG SQGIVQGTYE
160 170 180 190 200
TFVEAGRQHY QGSLKGRWVL TAGLGGMGGA QPLAATLAGA CSLNIECQQS
210 220 230 240 250
RIDFRLRTRY VDEQATSLDD ALARIKKYTA EGRAISIALC GNAADIVPEL
260 270 280 290 300
VKRGVRPDMV TDQTSAHDPL HGYLPKGWSW EEYQQKAESD PQGTILAAKR
310 320 330 340 350
SMADHVQAML AFNEMGVPTF DYGNNIRQMA QEMGVSNAFD FPGFVPAYIR
360 370 380 390 400
PLFCRGIGPF RWVALSGDPQ DIYKTDAKVK EIIKDDKHLH HWLDMARERI
410 420 430 440 450
SFQGLPARIC WVGLEWRQKL GLAFNEMVRS GEVSAPIVIG RDHLDSGSVA
460 470 480 490 500
SPNRETEAMR DGSDAVSDWP LLNALLNTAS GATWVSLHHG GGVGMGFSQH
510 520 530 540 550
SGMVIVCDGT DEAAARIARV LRNDPATGVM RHADAGYDIA IECAAEQGLN
560
LPMVAATQGN AK
Length:562
Mass (Da):61,562
Last modified:November 25, 2008 - v1
Checksum:i8F984F14F7AC1AC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI09126.1.
RefSeqiWP_012542404.1. NC_011283.1.
YP_002239597.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI09126; ACI09126; KPK_3778.
KEGGikpe:KPK_3778.
PATRICi20440839. VBIKlePne121904_3787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI09126.1.
RefSeqiWP_012542404.1. NC_011283.1.
YP_002239597.1. NC_011283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi507522.KPK_3778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI09126; ACI09126; KPK_3778.
KEGGikpe:KPK_3778.
PATRICi20440839. VBIKlePne121904_3787.

Phylogenomic databases

eggNOGiCOG2987.
HOGENOMiHOG000237606.
KOiK01712.
OMAiHEWAPRV.
OrthoDBiEOG62K1TR.

Enzyme and pathway databases

UniPathwayiUPA00379; UER00550.
BioCyciKPNE507522:GI0B-3779-MONOMER.

Family and domain databases

HAMAPiMF_00577. HutU.
InterProiIPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view]
PfamiPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMiSSF111326. SSF111326. 1 hit.
TIGRFAMsiTIGR01228. hutU. 1 hit.
PROSITEiPS01233. UROCANASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiHUTU_KLEP3
AccessioniPrimary (citable) accession number: B5XZ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: April 1, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.