SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B5XZ80

- HUTU_KLEP3

UniProt

B5XZ80 - HUTU_KLEP3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Urocanate hydratase

Gene
hutU, KPK_3778
Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotation

Cofactori

Binds 1 NAD per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101 By similarity

GO - Molecular functioni

  1. urocanate hydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
  2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-3779-MONOMER.
UniPathwayiUPA00379; UER00550.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocanate hydratase (EC:4.2.1.49)
Short name:
Urocanase
Alternative name(s):
Imidazolonepropionate hydrolase
Gene namesi
Name:hutU
Ordered Locus Names:KPK_3778
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Urocanate hydrataseUniRule annotationPRO_1000129565Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi507522.KPK_3778.

Family & Domainsi

Sequence similaritiesi

Belongs to the urocanase family.

Phylogenomic databases

eggNOGiCOG2987.
HOGENOMiHOG000237606.
KOiK01712.
OMAiLAFNEMG.
OrthoDBiEOG62K1TR.

Family and domain databases

HAMAPiMF_00577. HutU.
InterProiIPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view]
PfamiPF01175. Urocanase. 1 hit.
[Graphical view]
PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMiSSF111326. SSF111326. 1 hit.
TIGRFAMsiTIGR01228. hutU. 1 hit.
PROSITEiPS01233. UROCANASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XZ80-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSKYRQLD VRAPRGTTLT ARSWLTEAPL RMLMNNLDPD VAENPHELVV    50
YGGIGRAARN WECYDAIVKA LKNLESDETL LVQSGKPVGV FKTHENSPRV 100
LIANSNLVPH WATWEHFNEL DAKGLAMYGQ MTAGSWIYIG SQGIVQGTYE 150
TFVEAGRQHY QGSLKGRWVL TAGLGGMGGA QPLAATLAGA CSLNIECQQS 200
RIDFRLRTRY VDEQATSLDD ALARIKKYTA EGRAISIALC GNAADIVPEL 250
VKRGVRPDMV TDQTSAHDPL HGYLPKGWSW EEYQQKAESD PQGTILAAKR 300
SMADHVQAML AFNEMGVPTF DYGNNIRQMA QEMGVSNAFD FPGFVPAYIR 350
PLFCRGIGPF RWVALSGDPQ DIYKTDAKVK EIIKDDKHLH HWLDMARERI 400
SFQGLPARIC WVGLEWRQKL GLAFNEMVRS GEVSAPIVIG RDHLDSGSVA 450
SPNRETEAMR DGSDAVSDWP LLNALLNTAS GATWVSLHHG GGVGMGFSQH 500
SGMVIVCDGT DEAAARIARV LRNDPATGVM RHADAGYDIA IECAAEQGLN 550
LPMVAATQGN AK 562
Length:562
Mass (Da):61,562
Last modified:November 25, 2008 - v1
Checksum:i8F984F14F7AC1AC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI09126.1.
RefSeqiWP_012542404.1. NC_011283.1.
YP_002239597.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI09126; ACI09126; KPK_3778.
GeneIDi6935033.
KEGGikpe:KPK_3778.
PATRICi20440839. VBIKlePne121904_3787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI09126.1 .
RefSeqi WP_012542404.1. NC_011283.1.
YP_002239597.1. NC_011283.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 507522.KPK_3778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI09126 ; ACI09126 ; KPK_3778 .
GeneIDi 6935033.
KEGGi kpe:KPK_3778.
PATRICi 20440839. VBIKlePne121904_3787.

Phylogenomic databases

eggNOGi COG2987.
HOGENOMi HOG000237606.
KOi K01712.
OMAi LAFNEMG.
OrthoDBi EOG62K1TR.

Enzyme and pathway databases

UniPathwayi UPA00379 ; UER00550 .
BioCyci KPNE507522:GI0B-3779-MONOMER.

Family and domain databases

HAMAPi MF_00577. HutU.
InterProi IPR023637. Urocanase.
IPR023636. Urocanase_CS.
[Graphical view ]
Pfami PF01175. Urocanase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAMi SSF111326. SSF111326. 1 hit.
TIGRFAMsi TIGR01228. hutU. 1 hit.
PROSITEi PS01233. UROCANASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiHUTU_KLEP3
AccessioniPrimary (citable) accession number: B5XZ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi