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B5XZ80

- HUTU_KLEP3

UniProt

B5XZ80 - HUTU_KLEP3

Protein

Urocanate hydratase

Gene

hutU

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.UniRule annotation

    Cofactori

    Binds 1 NAD per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101UniRule annotation

    GO - Molecular functioni

    1. urocanate hydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
    2. histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Histidine metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-3779-MONOMER.
    UniPathwayiUPA00379; UER00550.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocanate hydrataseUniRule annotation (EC:4.2.1.49UniRule annotation)
    Short name:
    UrocanaseUniRule annotation
    Alternative name(s):
    Imidazolonepropionate hydrolaseUniRule annotation
    Gene namesi
    Name:hutUUniRule annotation
    Ordered Locus Names:KPK_3778
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Urocanate hydratasePRO_1000129565Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi507522.KPK_3778.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urocanase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2987.
    HOGENOMiHOG000237606.
    KOiK01712.
    OMAiLAFNEMG.
    OrthoDBiEOG62K1TR.

    Family and domain databases

    HAMAPiMF_00577. HutU.
    InterProiIPR023637. Urocanase.
    IPR023636. Urocanase_CS.
    [Graphical view]
    PfamiPF01175. Urocanase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001423. Urocanate_hydrat. 1 hit.
    SUPFAMiSSF111326. SSF111326. 1 hit.
    TIGRFAMsiTIGR01228. hutU. 1 hit.
    PROSITEiPS01233. UROCANASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5XZ80-1 [UniParc]FASTAAdd to Basket

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    MSQSKYRQLD VRAPRGTTLT ARSWLTEAPL RMLMNNLDPD VAENPHELVV    50
    YGGIGRAARN WECYDAIVKA LKNLESDETL LVQSGKPVGV FKTHENSPRV 100
    LIANSNLVPH WATWEHFNEL DAKGLAMYGQ MTAGSWIYIG SQGIVQGTYE 150
    TFVEAGRQHY QGSLKGRWVL TAGLGGMGGA QPLAATLAGA CSLNIECQQS 200
    RIDFRLRTRY VDEQATSLDD ALARIKKYTA EGRAISIALC GNAADIVPEL 250
    VKRGVRPDMV TDQTSAHDPL HGYLPKGWSW EEYQQKAESD PQGTILAAKR 300
    SMADHVQAML AFNEMGVPTF DYGNNIRQMA QEMGVSNAFD FPGFVPAYIR 350
    PLFCRGIGPF RWVALSGDPQ DIYKTDAKVK EIIKDDKHLH HWLDMARERI 400
    SFQGLPARIC WVGLEWRQKL GLAFNEMVRS GEVSAPIVIG RDHLDSGSVA 450
    SPNRETEAMR DGSDAVSDWP LLNALLNTAS GATWVSLHHG GGVGMGFSQH 500
    SGMVIVCDGT DEAAARIARV LRNDPATGVM RHADAGYDIA IECAAEQGLN 550
    LPMVAATQGN AK 562
    Length:562
    Mass (Da):61,562
    Last modified:November 25, 2008 - v1
    Checksum:i8F984F14F7AC1AC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI09126.1.
    RefSeqiWP_012542404.1. NC_011283.1.
    YP_002239597.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI09126; ACI09126; KPK_3778.
    GeneIDi6935033.
    KEGGikpe:KPK_3778.
    PATRICi20440839. VBIKlePne121904_3787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI09126.1 .
    RefSeqi WP_012542404.1. NC_011283.1.
    YP_002239597.1. NC_011283.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_3778.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI09126 ; ACI09126 ; KPK_3778 .
    GeneIDi 6935033.
    KEGGi kpe:KPK_3778.
    PATRICi 20440839. VBIKlePne121904_3787.

    Phylogenomic databases

    eggNOGi COG2987.
    HOGENOMi HOG000237606.
    KOi K01712.
    OMAi LAFNEMG.
    OrthoDBi EOG62K1TR.

    Enzyme and pathway databases

    UniPathwayi UPA00379 ; UER00550 .
    BioCyci KPNE507522:GI0B-3779-MONOMER.

    Family and domain databases

    HAMAPi MF_00577. HutU.
    InterProi IPR023637. Urocanase.
    IPR023636. Urocanase_CS.
    [Graphical view ]
    Pfami PF01175. Urocanase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001423. Urocanate_hydrat. 1 hit.
    SUPFAMi SSF111326. SSF111326. 1 hit.
    TIGRFAMsi TIGR01228. hutU. 1 hit.
    PROSITEi PS01233. UROCANASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiHUTU_KLEP3
    AccessioniPrimary (citable) accession number: B5XZ80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3