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B5XYZ0

- GPPA_KLEP3

UniProt

B5XYZ0 - GPPA_KLEP3

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, KPK_5399
Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-5400-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:KPK_5399
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_1000192530Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi507522.KPK_5399.

Structurei

3D structure databases

ProteinModelPortaliB5XYZ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XYZ0-1 [UniParc]FASTAAdd to Basket

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MSSTSLYAAI DLGSNSFHML VVREVAGSIQ TLSRIKRKVR LAAGLNSDNT    50
LSAEAMERGW QCLRLFAERL QDIPPTQIRV VATATLRLAV NAEEFLAKAQ 100
EILGTPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG 150
AQTTSLFSLS MGCVTWLERY FADRSLTKEN FDLAEAAARE VLLPIADVLR 200
YHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE 250
LEIEGLTLER ALVFPSGLAI LIAIFSELNI QCMTLAGGAL REGLVYGMLH 300
LSVEQDIRSR TLRNIQRRFM IDTEQAQRVA SLASHLLSQL DGSWELDPLS 350
RDLLLSACSL HEIGLSVDFK RAPQHAAYLV NNLDLPGFTP AQKKLIATLL 400
LNQTNAIDLS SLHQQNAVPP RVAEHLCRLL RLAILFASRR RDDLLPAIQL 450
AAHDDQLTLT LPENWLAEHP LGREMVDQEC QWQSYVHWTL RVTSGDTPR 499
Length:499
Mass (Da):55,167
Last modified:November 25, 2008 - v1
Checksum:iA9937C41BDBBF9B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI11046.1.
RefSeqiYP_002241153.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI11046; ACI11046; KPK_5399.
GeneIDi6937191.
KEGGikpe:KPK_5399.
PATRICi20443894. VBIKlePne121904_5258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI11046.1 .
RefSeqi YP_002241153.1. NC_011283.1.

3D structure databases

ProteinModelPortali B5XYZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 507522.KPK_5399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI11046 ; ACI11046 ; KPK_5399 .
GeneIDi 6937191.
KEGGi kpe:KPK_5399.
PATRICi 20443894. VBIKlePne121904_5258.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci KPNE507522:GI0B-5400-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiGPPA_KLEP3
AccessioniPrimary (citable) accession number: B5XYZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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