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Protein

Pantothenate kinase

Gene

coaA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi95 – 102ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:KPK_5321
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000999331 – 316Pantothenate kinaseAdd BLAST316

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 16Combined sources6
Helixi17 – 21Combined sources5
Helixi23 – 26Combined sources4
Helixi33 – 42Combined sources10
Helixi48 – 53Combined sources6
Helixi55 – 80Combined sources26
Beta strandi89 – 95Combined sources7
Helixi101 – 112Combined sources12
Helixi116 – 118Combined sources3
Beta strandi121 – 125Combined sources5
Helixi126 – 129Combined sources4
Helixi133 – 139Combined sources7
Helixi142 – 144Combined sources3
Helixi148 – 150Combined sources3
Helixi153 – 163Combined sources11
Turni164 – 166Combined sources3
Beta strandi170 – 172Combined sources3
Turni177 – 180Combined sources4
Beta strandi188 – 190Combined sources3
Beta strandi194 – 199Combined sources6
Turni201 – 204Combined sources4
Helixi207 – 209Combined sources3
Helixi219 – 222Combined sources4
Beta strandi224 – 230Combined sources7
Helixi233 – 250Combined sources18
Turni251 – 253Combined sources3
Helixi260 – 263Combined sources4
Helixi267 – 280Combined sources14
Helixi282 – 289Combined sources8
Helixi291 – 296Combined sources6
Beta strandi297 – 303Combined sources7
Helixi305 – 307Combined sources3
Beta strandi309 – 315Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F7WX-ray2.10A/B/C/D/E/F/G/H1-316[»]
4GI7X-ray1.95A/B/C/D/E/F/G/H1-316[»]
4NE2X-ray1.90A/B1-316[»]
SMRiB5XYG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Family and domain databases

CDDicd02025. PanK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XYG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKEQTLMT PYLQFNRHQW AALRDSVPMT LTEDEITRLK GINEDLSLEE
60 70 80 90 100
VAEIYLPLSR LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG
110 120 130 140 150
KSTTARVLQA LLSRWPEHRH VELITTDGFL HPNSVLKERG LMKKKGFPQS
160 170 180 190 200
YDMHRLVKFV SDLKSGVPQA TAPVYSHLIY DVIPDGDKTV AQPDILILEG
210 220 230 240 250
LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEELLKSWY INRFLKFREG
260 270 280 290 300
AFTDPDSYFH NYAKLSKEEA VDIATSLWNE INLMNLKENI LPTRERASLI
310
MTKSANHSVN QVRLRK
Length:316
Mass (Da):36,214
Last modified:November 25, 2008 - v1
Checksum:iC5237900E1764043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11207.1.

Genome annotation databases

EnsemblBacteriaiACI11207; ACI11207; KPK_5321.
KEGGikpe:KPK_5321.
PATRICi20443740. VBIKlePne121904_5190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11207.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F7WX-ray2.10A/B/C/D/E/F/G/H1-316[»]
4GI7X-ray1.95A/B/C/D/E/F/G/H1-316[»]
4NE2X-ray1.90A/B1-316[»]
SMRiB5XYG3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI11207; ACI11207; KPK_5321.
KEGGikpe:KPK_5321.
PATRICi20443740. VBIKlePne121904_5190.

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

CDDicd02025. PanK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA_KLEP3
AccessioniPrimary (citable) accession number: B5XYG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.