Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pantothenate kinase

Gene

coaA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1028ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-5322-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:KPK_5321
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Pantothenate kinasePRO_1000099933Add
BLAST

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 166Combined sources
Helixi17 – 215Combined sources
Helixi23 – 264Combined sources
Helixi33 – 4210Combined sources
Helixi48 – 536Combined sources
Helixi55 – 8026Combined sources
Beta strandi89 – 957Combined sources
Helixi101 – 11212Combined sources
Helixi116 – 1183Combined sources
Beta strandi121 – 1255Combined sources
Helixi126 – 1294Combined sources
Helixi133 – 1397Combined sources
Helixi142 – 1443Combined sources
Helixi148 – 1503Combined sources
Helixi153 – 16311Combined sources
Turni164 – 1663Combined sources
Beta strandi170 – 1723Combined sources
Turni177 – 1804Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi194 – 1996Combined sources
Turni201 – 2044Combined sources
Helixi207 – 2093Combined sources
Helixi219 – 2224Combined sources
Beta strandi224 – 2307Combined sources
Helixi233 – 25018Combined sources
Turni251 – 2533Combined sources
Helixi260 – 2634Combined sources
Helixi267 – 28014Combined sources
Helixi282 – 2898Combined sources
Helixi291 – 2966Combined sources
Beta strandi297 – 3037Combined sources
Helixi305 – 3073Combined sources
Beta strandi309 – 3157Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F7WX-ray2.10A/B/C/D/E/F/G/H1-316[»]
4GI7X-ray1.95A/B/C/D/E/F/G/H1-316[»]
4NE2X-ray1.90A/B1-316[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XYG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKEQTLMT PYLQFNRHQW AALRDSVPMT LTEDEITRLK GINEDLSLEE
60 70 80 90 100
VAEIYLPLSR LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG
110 120 130 140 150
KSTTARVLQA LLSRWPEHRH VELITTDGFL HPNSVLKERG LMKKKGFPQS
160 170 180 190 200
YDMHRLVKFV SDLKSGVPQA TAPVYSHLIY DVIPDGDKTV AQPDILILEG
210 220 230 240 250
LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEELLKSWY INRFLKFREG
260 270 280 290 300
AFTDPDSYFH NYAKLSKEEA VDIATSLWNE INLMNLKENI LPTRERASLI
310
MTKSANHSVN QVRLRK
Length:316
Mass (Da):36,214
Last modified:November 25, 2008 - v1
Checksum:iC5237900E1764043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11207.1.

Genome annotation databases

EnsemblBacteriaiACI11207; ACI11207; KPK_5321.
KEGGikpe:KPK_5321.
PATRICi20443740. VBIKlePne121904_5190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI11207.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F7WX-ray2.10A/B/C/D/E/F/G/H1-316[»]
4GI7X-ray1.95A/B/C/D/E/F/G/H1-316[»]
4NE2X-ray1.90A/B1-316[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI11207; ACI11207; KPK_5321.
KEGGikpe:KPK_5321.
PATRICi20443740. VBIKlePne121904_5190.

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciKPNE507522:GI0B-5322-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA_KLEP3
AccessioniPrimary (citable) accession number: B5XYG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.