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Protein

Catalase-peroxidase

Gene

katG

Organism
Klebsiella pneumoniae (strain 342)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotationSAAS annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotationSAAS annotation
Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotationSAAS annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Transition state stabilizerUniRule annotation1
Active sitei106Proton acceptorUniRule annotation1
Metal bindingi267Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotationSAAS annotation

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotationImported
Ordered Locus Names:KPK_2536Imported
OrganismiKlebsiella pneumoniae (strain 342)Imported
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki105 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-105)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 424PEROXIDASE_4InterPro annotationAdd BLAST286

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XX53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSNDPSNN ASAGKCPFHA ETPKQSAGSG TGNRDWWPNQ LRVDLLNQHS
60 70 80 90 100
SRSNPLGEDF NYREEFKKLD YSALKADLRA LLTDSQEWWP ADWGSYIGLF
110 120 130 140 150
IRMAWHGAGT YRTVDGRGGA GRGQQRFAPL NSWPDNVSLD KARRLLWPVK
160 170 180 190 200
QKYGQKISWA DLYMLAGNVA LENAGFRTFG FGAGREDVWE PDLDVDWGDE
210 220 230 240 250
KEWLAHRHPE SLAKQAIGAT EMGLIYVNPE GPNASGEPLS AAAAIRATFG
260 270 280 290 300
NMAMDDEEIV ALIAGGHTLG KTHGAAETSH VGAEPEAAPL EAQGLGWHSS
310 320 330 340 350
YGSGAGADAI TSGLEVVWTQ TPTQWSNYFF ENLFKYEWVQ TRSPAGAIQF
360 370 380 390 400
EAKDAPEIIP DPFNPGKKRK PTMLVTDLTL RFDPEFEKIS RRFLNDPQAF
410 420 430 440 450
NEAFARAWFK LTHRDMGPKS RYLGPEVPKE DLIWQDPLPA ATHQPSAEDI
460 470 480 490 500
ASLKTAIAGA GLSVSELVSV AWASASTFRG GDKRGGANGA RLALAPQKDW
510 520 530 540 550
PVNAIASRVL PTLQAIQRAS GKASLADIIV LAGVVGVEQA AAAAGVSVNV
560 570 580 590 600
PFTPGRVDAL PEQTDVESFD LLQPLADGFR NYRRIEGGVS TETLLIDKAQ
610 620 630 640 650
QLTLTAPEMT VLVGGLRVLG ANYDGSKHGV FTDRVGVLSN DFFVNLLDMA
660 670 680 690 700
TVWKAADDHA ELFTGSDRKT GEAKYSATRV DLVFGSNSVL RALAEVYACA
710 720
DGQQKLVHDF VAAWTKVMNL DRFDL
Length:725
Mass (Da):78,876
Last modified:November 25, 2008 - v1
Checksum:i38182151496AA49F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI07402.1.
RefSeqiWP_012541632.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI07402; ACI07402; KPK_2536.
KEGGikpe:KPK_2536.
PATRICi20438492. VBIKlePne121904_2618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI07402.1.
RefSeqiWP_012541632.1. NC_011283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI07402; ACI07402; KPK_2536.
KEGGikpe:KPK_2536.
PATRICi20438492. VBIKlePne121904_2618.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB5XX53_KLEP3
AccessioniPrimary (citable) accession number: B5XX53
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.