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B5XWU5 (B5XWU5_KLEP3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-aminobutyraldehyde dehydrogenase HAMAP MF_01275
EC=1.2.1.19 HAMAP MF_01275
Alternative name(s):
1-pyrroline dehydrogenase HAMAP MF_01275
4-aminobutanal dehydrogenase HAMAP MF_01275
Gene names
Name:ydcW EMBL ACI11654.1
Synonyms:prr HAMAP MF_01275
Ordered Locus Names:KPK_2428
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP] EMBL ACI11654.1
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) By similarity. HAMAP MF_01275

Catalytic activity

4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH. HAMAP MF_01275

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1. HAMAP MF_01275

Subunit structure

Homotetramer By similarity. HAMAP MF_01275

Miscellaneous

4-aminobutanal is also called gamma-aminobutyraldehyde By similarity. HAMAP MF_01275

Sequence similarities

Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily. HAMAP MF_01275

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding172 – 1754NAD By similarity HAMAP MF_01275
Nucleotide binding225 – 2317NAD By similarity HAMAP MF_01275

Sites

Active site2461 By similarity HAMAP MF_01275
Active site2801Nucleophile By similarity HAMAP MF_01275
Binding site1461NAD; via carbonyl oxygen By similarity HAMAP MF_01275
Binding site2091NAD By similarity HAMAP MF_01275

Sequences

Sequence LengthMass (Da)Tools
B5XWU5 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 54D9E00E10883F68

FASTA47550,529
        10         20         30         40         50         60 
MQHNLLINGK LVAGEGEKVP VYNPATGDVI LEIAEATAAQ VDAAVEAADR AFDAWSQTTP 

        70         80         90        100        110        120 
KTRSECLLKL ADAIAAQAET LAQLESLNCG KPLHCVINDE MPAIADVFRF FAGAARCLPG 

       130        140        150        160        170        180 
MAAGEYLEGH TSMIRRDPVG VVASIAPWNY PLMMAAWKLA PALAAGNCVV IKPSEITPLT 

       190        200        210        220        230        240 
ALKLAELAKD IFPEGVINVL FGRGKTVGDP LTSHAKVRMV SLTGSIATGA HIISHTASSI 

       250        260        270        280        290        300 
KRTHMELGGK APVIVFDDAD IDAVVDGVRT FGFYNAGQDC TAACRIYAQQ GIYDQLVEKL 

       310        320        330        340        350        360 
GAAVASLKMG APEDASTELG PLSSLAHLER VSAAVEAAKA LPHIKVVTGG RRADGAGYYF 

       370        380        390        400        410        420 
QPTLLAGARQ EDAIVQREVF GPVVSVTPFS DEAQALSWAN DSQYGLASSV WTKDVGRAHR 

       430        440        450        460        470 
LSARLQYGCT WVNTHFMLVS EMPHGGQKLS GYGKDMSMYG LEDYTVVRHV MVKHG

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000964 Genomic DNA. Translation: ACI11654.1.
RefSeqYP_002238259.1. NC_011283.1.

3D structure databases

ProteinModelPortalB5XWU5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5XWU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6934957.
GenomeReviewsGene locus KPK_2428 in contig CP000964_GR.
KEGGkpe:KPK_2428.
PATRIC20438286. VBIKlePne121904_2515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMACRIYAQQ.
ProtClustDBPRK13473.

Family and domain databases

HAMAPMF_01275. Aldedh_Prr.
[Tree]
InterProIPR017749. 1-pyrroline_dehydrogenase.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00137.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03374. ABALDH. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5XWU5_KLEP3
AccessionPrimary (citable) accession number: B5XWU5
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info