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B5XUY5 (FUCI_KLEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:KPK_0964
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP]
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-fucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591L-fucose isomerase HAMAP-Rule MF_01254
PRO_1000139956

Sites

Active site3371Proton acceptor By similarity
Active site3611Proton acceptor By similarity
Metal binding3371Manganese By similarity
Metal binding3611Manganese By similarity
Metal binding5281Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
B5XUY5 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: E93126B338220AC9

FASTA59164,737
        10         20         30         40         50         60 
MKKISLPKIG IRPVIDGRRM GVRESLEAQT MNMAKATAAL ISEKLRHACG ARVECVIADT 

        70         80         90        100        110        120 
CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD PLRPKAIWGF NGTERPGAVY 

       130        140        150        160        170        180 
LAAALAAHSQ KGIPAFSIYG HDVQDADDTS IPADVEEKLL RFARAGLAVA SMKGKSYLSL 

       190        200        210        220        230        240 
GGVSMGIAGS IVDHNFFESW LGMKVQAVDM TELRRRIDQK IYDETELEMA LAWADKHFRY 

       250        260        270        280        290        300 
GEDQNAEQYK RNETQSRAVL KESLLMAMCI RDMMQGNPKL AEKGLVEESL GYNAIAAGFQ 

       310        320        330        340        350        360 
GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLMGH QLTGTAQVFA 

       370        380        390        400        410        420 
DVRTYWSPDA VERVTGQPLT GRAEHGIIHL INSGSAALDG SCQQRDAQGN PTMKPHWEIE 

       430        440        450        460        470        480 
QNEADACLAA TEWCPAIHEY FRGGGFSSRF LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS 

       490        500        510        520        530        540 
VALPKAMHDQ LDARTNSTWP TTWFAPRLTG KGPFSDVYSV MANWGANHGV LTIGHVGADF 

       550        560        570        580        590 
ITLAAMLRIP VCMHNVEAAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 342.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000964 Genomic DNA. Translation: ACI07585.1.
RefSeqYP_002236834.1. NC_011283.1.

3D structure databases

ProteinModelPortalB5XUY5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING507522.KPK_0964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI07585; ACI07585; KPK_0964.
GeneID6936697.
KEGGkpe:KPK_0964.
PATRIC20435508. VBIKlePne121904_1159.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2407.
HOGENOMHOG000249674.
KOK01818.
OMAKEGQDYR.
OrthoDBEOG6FJNCF.

Enzyme and pathway databases

BioCycKPNE507522:GI0B-966-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_KLEP3
AccessionPrimary (citable) accession number: B5XUY5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways