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B5XUY5

- FUCI_KLEP3

UniProt

B5XUY5 - FUCI_KLEP3

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Protein
L-fucose isomerase
Gene
fucI, KPK_0964
Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 3371Proton acceptor By similarity
Metal bindingi337 – 3371Manganese By similarity
Active sitei361 – 3611Proton acceptor By similarity
Metal bindingi361 – 3611Manganese By similarity
Metal bindingi528 – 5281Manganese By similarity

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-966-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomerase (EC:5.3.1.25)
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene namesi
Name:fucI
Ordered Locus Names:KPK_0964
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591L-fucose isomeraseUniRule annotation
PRO_1000139956Add
BLAST

Interactioni

Subunit structurei

Homohexamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi507522.KPK_0964.

Structurei

3D structure databases

ProteinModelPortaliB5XUY5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiKEGQDYR.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XUY5-1 [UniParc]FASTAAdd to Basket

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MKKISLPKIG IRPVIDGRRM GVRESLEAQT MNMAKATAAL ISEKLRHACG    50
ARVECVIADT CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD 100
PLRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS 150
IPADVEEKLL RFARAGLAVA SMKGKSYLSL GGVSMGIAGS IVDHNFFESW 200
LGMKVQAVDM TELRRRIDQK IYDETELEMA LAWADKHFRY GEDQNAEQYK 250
RNETQSRAVL KESLLMAMCI RDMMQGNPKL AEKGLVEESL GYNAIAAGFQ 300
GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLMGH 350
QLTGTAQVFA DVRTYWSPDA VERVTGQPLT GRAEHGIIHL INSGSAALDG 400
SCQQRDAQGN PTMKPHWEIE QNEADACLAA TEWCPAIHEY FRGGGFSSRF 450
LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VALPKAMHDQ LDARTNSTWP 500
TTWFAPRLTG KGPFSDVYSV MANWGANHGV LTIGHVGADF ITLAAMLRIP 550
VCMHNVEAAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 591
Length:591
Mass (Da):64,737
Last modified:November 25, 2008 - v1
Checksum:iE93126B338220AC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI07585.1.
RefSeqiYP_002236834.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI07585; ACI07585; KPK_0964.
GeneIDi6936697.
KEGGikpe:KPK_0964.
PATRICi20435508. VBIKlePne121904_1159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI07585.1 .
RefSeqi YP_002236834.1. NC_011283.1.

3D structure databases

ProteinModelPortali B5XUY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 507522.KPK_0964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI07585 ; ACI07585 ; KPK_0964 .
GeneIDi 6936697.
KEGGi kpe:KPK_0964.
PATRICi 20435508. VBIKlePne121904_1159.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000249674.
KOi K01818.
OMAi KEGQDYR.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci KPNE507522:GI0B-966-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiFUCI_KLEP3
AccessioniPrimary (citable) accession number: B5XUY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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