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B5XUY5

- FUCI_KLEP3

UniProt

B5XUY5 - FUCI_KLEP3

Protein

L-fucose isomerase

Gene

fucI

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei337 – 3371Proton acceptorUniRule annotation
    Metal bindingi337 – 3371ManganeseUniRule annotation
    Active sitei361 – 3611Proton acceptorUniRule annotation
    Metal bindingi361 – 3611ManganeseUniRule annotation
    Metal bindingi528 – 5281ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-966-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:KPK_0964
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591L-fucose isomerasePRO_1000139956Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi507522.KPK_0964.

    Structurei

    3D structure databases

    ProteinModelPortaliB5XUY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5XUY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKISLPKIG IRPVIDGRRM GVRESLEAQT MNMAKATAAL ISEKLRHACG    50
    ARVECVIADT CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD 100
    PLRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS 150
    IPADVEEKLL RFARAGLAVA SMKGKSYLSL GGVSMGIAGS IVDHNFFESW 200
    LGMKVQAVDM TELRRRIDQK IYDETELEMA LAWADKHFRY GEDQNAEQYK 250
    RNETQSRAVL KESLLMAMCI RDMMQGNPKL AEKGLVEESL GYNAIAAGFQ 300
    GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLMGH 350
    QLTGTAQVFA DVRTYWSPDA VERVTGQPLT GRAEHGIIHL INSGSAALDG 400
    SCQQRDAQGN PTMKPHWEIE QNEADACLAA TEWCPAIHEY FRGGGFSSRF 450
    LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VALPKAMHDQ LDARTNSTWP 500
    TTWFAPRLTG KGPFSDVYSV MANWGANHGV LTIGHVGADF ITLAAMLRIP 550
    VCMHNVEAAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 591
    Length:591
    Mass (Da):64,737
    Last modified:November 25, 2008 - v1
    Checksum:iE93126B338220AC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI07585.1.
    RefSeqiYP_002236834.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI07585; ACI07585; KPK_0964.
    GeneIDi6936697.
    KEGGikpe:KPK_0964.
    PATRICi20435508. VBIKlePne121904_1159.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI07585.1 .
    RefSeqi YP_002236834.1. NC_011283.1.

    3D structure databases

    ProteinModelPortali B5XUY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_0964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI07585 ; ACI07585 ; KPK_0964 .
    GeneIDi 6936697.
    KEGGi kpe:KPK_0964.
    PATRICi 20435508. VBIKlePne121904_1159.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci KPNE507522:GI0B-966-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiFUCI_KLEP3
    AccessioniPrimary (citable) accession number: B5XUY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3