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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-920-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:KPK_0919
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000133738Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XUU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQTFDAPV WHHGKALRKG YTTGSCATAA AKVAALMVMR QHLIHQVSIV
60 70 80 90 100
TPSGVTLCLN VESPHVEGQQ AVAAIRKDGG DDVDATHGML IFARVTLNDS
110 120 130 140 150
GEISLLGGEG IGTVTRKGIG LPTGSPAINR TPRHTIETAV REAIGPSRGA
160 170 180 190 200
QVEIFAPEGV LRAQKTYNAR LGILGGISII GTTGIVTPMS EESWKRSLSL
210 220 230 240 250
ELEIKRAAGL DRVVLVPGNH GERFVREQMG IDPQVVVTMS NFVGYMIEEA
260 270 280 290 300
VRLGFRQIVL IGHPGKLIKI AAGIFHTHSH IADARMETLV AHLALLGAPL
310 320 330 340 350
PLLTLVSECD TTEAAMEHID AWGYQRLYNH LAERICQRVL EMLRFTQHPP
360 370
ACDAVLFSFD NQVLGSSRPL AAIARELTC
Length:379
Mass (Da):40,870
Last modified:November 25, 2008 - v1
Checksum:iEDF1B65288F0A855
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI08091.1.
RefSeqiWP_012540683.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI08091; ACI08091; KPK_0919.
KEGGikpe:KPK_0919.
PATRICi20435416. VBIKlePne121904_1116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI08091.1.
RefSeqiWP_012540683.1. NC_011283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI08091; ACI08091; KPK_0919.
KEGGikpe:KPK_0919.
PATRICi20435416. VBIKlePne121904_1116.

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciKPNE507522:GI0B-920-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD. 1 hit.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBID_KLEP3
AccessioniPrimary (citable) accession number: B5XUU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.