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B5XUD5

- GCSP_KLEP3

UniProt

B5XUD5 - GCSP_KLEP3

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-761-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:KPK_0761
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000132443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB5XUD5.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi507522.KPK_0761.

    Structurei

    3D structure databases

    ProteinModelPortaliB5XUD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5XUD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTLSQLEN RDAFIERHIG PDAQQQQEML KTVGADSLNA LIGQIVPQDI    50
    QLATPPQVGD ATTEFAALAE LKAIAGRNKR FKSYIGMGYT AVQLPPVIQR 100
    NMLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTLDLTGL DIASASLLDE 150
    ATAAAEAMAM AKRVSKLKNA NRFFVAADVH PQTLDVVRTR AETFGFDVIV 200
    DDADKVLDHQ DVFGVLLQQV GTTGEIHDYS KLIAELKARK VIVSVAADFM 250
    ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAK DEFKRSMPGR 300
    IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
    FHGPAGLKRI AGRIHRLTDI LADGLQKKGL KLRHAHYFDT LCVEVADKAA 400
    VLARAEALQI NLRSDIHGAV GITLDEATTR EDVLNLFRAI VGDDHGLDID 450
    TLDKDVALDS RSIPAAMLRD DAILTHPVFN RYHSETEMMR YMHALERKDL 500
    ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPVE QAEGYHQMIA 550
    QLSDWLVKLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 600
    PSSAHGTNPA SAQMAGMQVV VVACDKNGNI DLADLREKAE QAGANLSCIM 650
    VTYPSTHGVY EETIREVCEI VHQFGGQVYL DGANMNAQVG ITSPGFIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIEGMLTRQG 750
    AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQNAILNAN YIATRLKEAY 800
    PVLYTGRDGR VAHECILDIR PLKEETGISE LDIAKRLIDF GFHAPTMSFP 850
    VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIDRVKAGEW PLEDNPLVNA 900
    PHTQGELVSE WNHPYSRELA VFPAGLHNKY WPTVKRLDDV YGDRNLFCSC 950
    VPMSEYQ 957
    Length:957
    Mass (Da):104,613
    Last modified:November 25, 2008 - v1
    Checksum:iF3B61A7CD2E87FB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06995.1.
    RefSeqiYP_002236634.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI06995; ACI06995; KPK_0761.
    GeneIDi6936029.
    KEGGikpe:KPK_0761.
    PATRICi20435118. VBIKlePne121904_0968.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06995.1 .
    RefSeqi YP_002236634.1. NC_011283.1.

    3D structure databases

    ProteinModelPortali B5XUD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_0761.

    Proteomic databases

    PRIDEi B5XUD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI06995 ; ACI06995 ; KPK_0761 .
    GeneIDi 6936029.
    KEGGi kpe:KPK_0761.
    PATRICi 20435118. VBIKlePne121904_0968.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci KPNE507522:GI0B-761-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiGCSP_KLEP3
    AccessioniPrimary (citable) accession number: B5XUD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3