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B5XTX7 (RLMG_KLEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174
Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG
Gene names
Name:rlmG
Ordered Locus Names:KPK_0601
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP]
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859

Catalytic activity

S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859

Subcellular location

Cytoplasm Potential HAMAP MF_01859.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

rRNA (guanine-N2-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859
PRO_0000366466

Sequences

Sequence LengthMass (Da)Tools
B5XTX7 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 0018A53A43BED380

FASTA37641,845
        10         20         30         40         50         60 
MSQAELNGEL FTLERFPPNA EEEALQAWEA ADEYLLQQVN DVDGLTLIFN DGFGALACAL 

        70         80         90        100        110        120 
AERNPVSIND SFISELATRH NLRMNGIDEE SVRFQDSLSP LPAAPALVLI KVPKQLALLE 

       130        140        150        160        170        180 
QQLRALREVV TPETRIIAAA KARDVHNSTL ALFEKILGTT TTSLAWKKAR LIHCVFTAPK 

       190        200        210        220        230        240 
LADAPQTYSW KLDGTPWTIH NHANVFARSG LDIGARFFLQ HLPSDLEGEI ADLGCGNGVI 

       250        260        270        280        290        300 
GLQALAQNPN ASVMFTDESH MAVASSRLNV ERNLPDDIAR CEFMVNNSLS GIEPDRFTAI 

       310        320        330        340        350        360 
LCNPPFHQQH AITDHIAWQM FNDARRSLKY GGELYVVGNR HLDYFRKLKR AFGNCTTIAT 

       370 
NNKFVILKAT KVRKQR

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 342.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000964 Genomic DNA. Translation: ACI11829.1.
RefSeqYP_002236476.1. NC_011283.1.

3D structure databases

ProteinModelPortalB5XTX7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5XTX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6939374.
GenomeReviewsGene locus KPK_0601 in contig CP000964_GR.
KEGGkpe:KPK_0601.
PATRIC20434801. VBIKlePne121904_0812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG321931.
OMANRHLGYH.
ProtClustDBCLSK2505749.

Family and domain databases

HAMAPMF_01859. 23SrRNA_methyltr_G.
[Tree]
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR007848. Small_mtfrase.
[Graphical view]
KOK11391.
PfamPF05175. MTS. 1 hit.
[Graphical view]
PIRSFPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMG_KLEP3
AccessionPrimary (citable) accession number: B5XTX7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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