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B5XTL0

- ARND_KLEP3

UniProt

B5XTL0 - ARND_KLEP3

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Protein
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Gene
arnD, KPK_0269
Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity.UniRule annotation

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-269-MONOMER.
UniPathwayiUPA00030.
UPA00036; UER00496.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (EC:3.5.1.n3)
Gene namesi
Name:arnD
Ordered Locus Names:KPK_0269
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation
PRO_0000383515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi507522.KPK_0269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 260259NodB homology
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0726.
HOGENOMiHOG000261199.
KOiK13014.
OMAiLHAWDHF.
OrthoDBiEOG6423D0.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
HAMAPiMF_01870. ArnD.
InterProiIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 2 hits.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XTL0-1 [UniParc]FASTAAdd to Basket

« Hide

MKQVGLRIDV DTFRGTRDGV PRLLDLLGQH GIQASFFFSV GPDNMGRHLW    50
RLVKPKFLWK MLRSRAASLY GWDILLAGTA WPGRRIGAGN EAVIRAAAES 100
HEVGLHAWDH YSWQAWSGVW PQERLALEVE RGLLELERII GRPVTCSAVA 150
GWRADQRVVK AKESFDFLYN SDCRGTRPFL PQLGSGTFGT VQIPVTLPTW 200
DEAVGTAVDI AGFNRYLLDC IHRDPGVPVY TIHAEVEGIA YADQFNELLT 250
MAAEEEIQFC PLSQLLPADF SELPSGKVVR GELAGREGWL GREQLLTSGV 300
Length:300
Mass (Da):33,397
Last modified:November 25, 2008 - v1
Checksum:i88945D5D48B740D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI06567.1.
RefSeqiYP_002236151.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI06567; ACI06567; KPK_0269.
GeneIDi6939097.
KEGGikpe:KPK_0269.
PATRICi20434140. VBIKlePne121904_0489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000964 Genomic DNA. Translation: ACI06567.1 .
RefSeqi YP_002236151.1. NC_011283.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 507522.KPK_0269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI06567 ; ACI06567 ; KPK_0269 .
GeneIDi 6939097.
KEGGi kpe:KPK_0269.
PATRICi 20434140. VBIKlePne121904_0489.

Phylogenomic databases

eggNOGi COG0726.
HOGENOMi HOG000261199.
KOi K13014.
OMAi LHAWDHF.
OrthoDBi EOG6423D0.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00036 ; UER00496 .
BioCyci KPNE507522:GI0B-269-MONOMER.

Family and domain databases

Gene3Di 3.20.20.370. 2 hits.
HAMAPi MF_01870. ArnD.
InterProi IPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view ]
Pfami PF01522. Polysacc_deac_1. 1 hit.
[Graphical view ]
SUPFAMi SSF88713. SSF88713. 2 hits.
PROSITEi PS51677. NODB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiARND_KLEP3
AccessioniPrimary (citable) accession number: B5XTL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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