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B5XTG2

- SLMA_KLEP3

UniProt

B5XTG2 - SLMA_KLEP3

Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. negative regulation of barrier septum assembly Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-113-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoid occlusion factor SlmAUniRule annotation
    Gene namesi
    Name:slmAUniRule annotation
    Ordered Locus Names:KPK_0113
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotation

    GO - Cellular componenti

    1. bacterial nucleoid Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Nucleoid occlusion factor SlmAPRO_1000188391Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FtsZ.UniRule annotation

    Protein-protein interaction databases

    STRINGi507522.KPK_0113.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2415
    Helixi26 – 294
    Helixi34 – 418
    Helixi45 – 517
    Helixi55 – 8026
    Helixi84 – 10118
    Helixi103 – 1097
    Helixi113 – 1164
    Helixi119 – 14729
    Helixi155 – 17521
    Turni176 – 1783
    Turni182 – 1854
    Helixi186 – 1949

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GCKX-ray2.05A/B/C/D1-198[»]
    4GFLX-ray2.30A/B1-198[»]
    ProteinModelPortaliB5XTG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7061HTH tetR-typeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili119 – 14426UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000266053.
    KOiK05501.
    OMAiEKDTSAR.
    OrthoDBiEOG6G7R3C.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01839. NO_factor_SlmA.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5XTG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR    50
    HFPSKTRMFD SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLILGFGE 100
    RNPGLTRILT GHALMFEQDR LQGRINQLFE RIEVQLRQVM REKKMREGEG 150
    YTLDETLLAS QLLAFCEGML SRFVRSEFKY RPTDDFEARW PLVAAQLQ 198
    Length:198
    Mass (Da):22,866
    Last modified:November 25, 2008 - v1
    Checksum:iBC44ACAC8F5023AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06851.1.
    RefSeqiYP_002235997.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI06851; ACI06851; KPK_0113.
    GeneIDi6937651.
    KEGGikpe:KPK_0113.
    PATRICi20433836. VBIKlePne121904_0338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI06851.1 .
    RefSeqi YP_002235997.1. NC_011283.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GCK X-ray 2.05 A/B/C/D 1-198 [» ]
    4GFL X-ray 2.30 A/B 1-198 [» ]
    ProteinModelPortali B5XTG2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_0113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI06851 ; ACI06851 ; KPK_0113 .
    GeneIDi 6937651.
    KEGGi kpe:KPK_0113.
    PATRICi 20433836. VBIKlePne121904_0338.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000266053.
    KOi K05501.
    OMAi EKDTSAR.
    OrthoDBi EOG6G7R3C.

    Enzyme and pathway databases

    BioCyci KPNE507522:GI0B-113-MONOMER.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01839. NO_factor_SlmA.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiSLMA_KLEP3
    AccessioniPrimary (citable) accession number: B5XTG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3