Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B5XTG2 (SLMA_KLEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoid occlusion factor SlmA
Gene names
Name:slmA
Ordered Locus Names:KPK_0113
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP]
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity. HAMAP-Rule MF_01839

Subunit structure

Homodimer By similarity. Interacts with FtsZ By similarity. HAMAP-Rule MF_01839

Subcellular location

Cytoplasmnucleoid By similarity HAMAP-Rule MF_01839.

Sequence similarities

Belongs to the nucleoid occlusion factor SlmA family.

Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
   DomainCoiled coil
   LigandDNA-binding
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of barrier septum assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentbacterial nucleoid

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Nucleoid occlusion factor SlmA HAMAP-Rule MF_01839
PRO_1000188391

Regions

Domain10 – 7061HTH tetR-type
DNA binding33 – 5220H-T-H motif By similarity
Coiled coil119 – 14426 Potential

Secondary structure

......................... 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
B5XTG2 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: BC44ACAC8F5023AA

FASTA19822,866
        10         20         30         40         50         60 
MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR HFPSKTRMFD 

        70         80         90        100        110        120 
SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLILGFGE RNPGLTRILT GHALMFEQDR 

       130        140        150        160        170        180 
LQGRINQLFE RIEVQLRQVM REKKMREGEG YTLDETLLAS QLLAFCEGML SRFVRSEFKY 

       190 
RPTDDFEARW PLVAAQLQ 

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 342.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000964 Genomic DNA. Translation: ACI06851.1.
RefSeqYP_002235997.1. NC_011283.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCKX-ray2.05A/B/C/D1-198[»]
4GFLX-ray2.30A/B1-198[»]
ProteinModelPortalB5XTG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING507522.KPK_0113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI06851; ACI06851; KPK_0113.
GeneID6937651.
KEGGkpe:KPK_0113.
PATRIC20433836. VBIKlePne121904_0338.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000266053.
KOK05501.
OMAEKDTSAR.
OrthoDBEOG6G7R3C.

Enzyme and pathway databases

BioCycKPNE507522:GI0B-113-MONOMER.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
HAMAPMF_01839. NO_factor_SlmA.
InterProIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLMA_KLEP3
AccessionPrimary (citable) accession number: B5XTG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references