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Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmAUniRule annotation
Gene namesi
Name:slmAUniRule annotation
Ordered Locus Names:KPK_0113
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasmnucleoid UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001883911 – 198Nucleoid occlusion factor SlmAAdd BLAST198

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.UniRule annotation

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 24Combined sources15
Helixi26 – 29Combined sources4
Helixi34 – 41Combined sources8
Helixi45 – 51Combined sources7
Helixi55 – 80Combined sources26
Helixi84 – 101Combined sources18
Helixi103 – 109Combined sources7
Helixi113 – 116Combined sources4
Helixi119 – 147Combined sources29
Helixi155 – 175Combined sources21
Turni176 – 178Combined sources3
Turni182 – 185Combined sources4
Helixi186 – 194Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GCKX-ray2.05A/B/C/D1-198[»]
4GFLX-ray2.30A/B1-198[»]
ProteinModelPortaliB5XTG2.
SMRiB5XTG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typeUniRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 144UniRule annotationAdd BLAST26

Sequence similaritiesi

Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000266053.
KOiK05501.
OMAiIEQTVFG.

Family and domain databases

HAMAPiMF_01839. NO_factor_SlmA. 1 hit.
InterProiView protein in InterPro
IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XTG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR
60 70 80 90 100
HFPSKTRMFD SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLILGFGE
110 120 130 140 150
RNPGLTRILT GHALMFEQDR LQGRINQLFE RIEVQLRQVM REKKMREGEG
160 170 180 190
YTLDETLLAS QLLAFCEGML SRFVRSEFKY RPTDDFEARW PLVAAQLQ
Length:198
Mass (Da):22,866
Last modified:November 25, 2008 - v1
Checksum:iBC44ACAC8F5023AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06851.1.
RefSeqiWP_008806831.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI06851; ACI06851; KPK_0113.
KEGGikpe:KPK_0113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06851.1.
RefSeqiWP_008806831.1. NC_011283.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GCKX-ray2.05A/B/C/D1-198[»]
4GFLX-ray2.30A/B1-198[»]
ProteinModelPortaliB5XTG2.
SMRiB5XTG2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI06851; ACI06851; KPK_0113.
KEGGikpe:KPK_0113.

Phylogenomic databases

HOGENOMiHOG000266053.
KOiK05501.
OMAiIEQTVFG.

Family and domain databases

HAMAPiMF_01839. NO_factor_SlmA. 1 hit.
InterProiView protein in InterPro
IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSLMA_KLEP3
AccessioniPrimary (citable) accession number: B5XTG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.