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Protein

Chitooligosaccharide deacetylase

Gene

chbG

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.UniRule annotation

Catalytic activityi

N,N'-diacetylchitobiose + H2O = N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine + acetate.UniRule annotation
Diacetylchitobiose-6-phosphate + H2O = N-monoacetylchitobiose-6-phosphate + acetate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: chitin degradation

This protein is involved in the pathway chitin degradation, which is part of Glycan degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway chitin degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Magnesium; via tele nitrogenUniRule annotation1
Metal bindingi125Magnesium; via pros nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00349

Names & Taxonomyi

Protein namesi
Recommended name:
Chitooligosaccharide deacetylaseUniRule annotation (EC:3.5.1.105UniRule annotation)
Short name:
CODUniRule annotation
Alternative name(s):
Chitin disaccharide deacetylaseUniRule annotation
Chitobiose deacetylaseUniRule annotation
Chitobiose-6P deacetylaseUniRule annotation
Chitotriose deacetylaseUniRule annotation
Chitotriose-6P deacetylaseUniRule annotation
Gene namesi
Name:chbGUniRule annotation
Ordered Locus Names:KPK_3206
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001398281 – 252Chitooligosaccharide deacetylaseAdd BLAST252

Proteomic databases

PRIDEiB5XT26

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiB5XT26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YdjC deacetylase family. ChbG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225034
KOiK03478
OMAiEPTHIDS

Family and domain databases

CDDicd10803 YdjC_EF3048_like, 1 hit
HAMAPiMF_01246 COD, 1 hit
InterProiView protein in InterPro
IPR022948 COD_ChbG_bac
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR006879 YdjC-like
PANTHERiPTHR31609 PTHR31609, 2 hits
PfamiView protein in Pfam
PF04794 YdjC, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit

Sequencei

Sequence statusi: Complete.

B5XT26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVLIVNAD DFGLSKGQNY GIIEACRNGV VTSTTALVNG AAIDHAAQLS
60 70 80 90 100
RSTPELAVGM HFVLTLGEPL SAMPGLTREG RLGKWIWQQA EEGRLPLEEI
110 120 130 140 150
AHELACQYRR FVDLFGHEPT HLDSHHHVHM IAPIYPIVAA FAREKGIALR
160 170 180 190 200
IDRQVAAQSG LDQQAARSSA GFSSEFYGEA VSEELFLQTL DASIARGERS
210 220 230 240 250
LEVMCHPAFV DQTIMGSAYC YPRLGELDVL TSAALKAAVA DRGYRLGTYR

DV
Length:252
Mass (Da):27,566
Last modified:November 25, 2008 - v1
Checksum:iC2A8C159AF51A4BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA Translation: ACI08028.1
RefSeqiWP_012542072.1, NC_011283.1

Genome annotation databases

EnsemblBacteriaiACI08028; ACI08028; KPK_3206
KEGGikpe:KPK_3206

Similar proteinsi

Entry informationi

Entry nameiCHBG_KLEP3
AccessioniPrimary (citable) accession number: B5XT26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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