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B5XS46 (B5XS46_KLEP3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase 2 HAMAP MF_01174
EC=1.2.1.71 HAMAP MF_01174
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase 2 HAMAP MF_01174
Gene names
Name:astD EMBL ACI10818.1
Synonyms:astD2 HAMAP MF_01174
Ordered Locus Names:KPK_3220
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP] EMBL ACI10818.1
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily. HAMAP MF_01174

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding220 – 2256NAD By similarity HAMAP MF_01174

Sites

Active site2431 By similarity HAMAP MF_01174
Active site2771 By similarity HAMAP MF_01174

Sequences

Sequence LengthMass (Da)Tools
B5XS46 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 4B27257DCDF4E0F5

FASTA49252,150
        10         20         30         40         50         60 
MSLWINGEWR PGRGPGFSKQ DPVNLKVVWQ GEAADAGQVA EAVAAARQAF PAWARLPFAA 

        70         80         90        100        110        120 
RQAIVEKFAA LLEASKTELT AMIGAETGKP RWEAAGEVTA MINKVAISVK AYNVRTGEQH 

       130        140        150        160        170        180 
SDLPDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS ELTPCSGEAV 

       190        200        210        220        230        240 
VKLWQQAGLP AGVLNLVQGG RETGESLSGQ ADIDGLLFTG SSTTGFHLHR QLAGQPQKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IVDDPRDVDA AVHLTIQSAF ITAGQRCTCA RRLLVRRGEA GDAFLSRLVT 

       310        320        330        340        350        360 
VSQRLIPAAW DAEPQPFLGG LISEPAAQKV HQAWLQRVAA GAVTLLEPRL LQAGTSLLTP 

       370        380        390        400        410        420 
GIVDMSDVAN VEDEEVFGPL LGVWRYDTFE EAIALANATR FGLSCGLISP EREKFDRLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTA PFGGTGASGN HRPGAWYAAD YCAWPMASLE SPTLTLPASL 

       490 
NPGLDFLAGE AS

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed: 18654632] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000964 Genomic DNA. Translation: ACI10818.1.
RefSeqYP_002239046.1. NC_011283.1.

3D structure databases

ProteinModelPortalB5XS46.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5XS46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6935840.
GenomeReviewsGene locus KPK_3220 in contig CP000964_GR.
KEGGkpe:KPK_3220.
PATRIC20439789. VBIKlePne121904_3266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMAKAYHART.
ProtClustDBCLSK2400673.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5XS46_KLEP3
AccessionPrimary (citable) accession number: B5XS46
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info