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B5XQU9

- GLSA_KLEP3

UniProt

B5XQU9 - GLSA_KLEP3

Protein

Glutaminase

Gene

glsA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciKPNE507522:GI0B-2744-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:KPK_2743
    OrganismiKlebsiella pneumoniae (strain 342)
    Taxonomic identifieri507522 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000001734: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GlutaminasePRO_1000115697Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi507522.KPK_2743.

    Structurei

    3D structure databases

    ProteinModelPortaliB5XQU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiMSIAVWS.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5XQU9-1 [UniParc]FASTAAdd to Basket

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    MAAVINNAML EAILAEIRPL IGRGKVADYI PALASVSGDK LGIAISTVDG    50
    QHFAAGDAHE RFSIQSISKV LSLVVAMNHY QEEEIWQRVG KDPSGQPFNS 100
    LLQLEIEQGK PRNPFINAGA LVVCDMLQSR LSAPRQRMLE IVRRLSGVAD 150
    IAYDPVVARS EFEHSARNAA IAWLMKSFGN FHNDVATVLQ NYFHYCSLEM 200
    SCVELARTFL FLADRGIAPH LEAPVIAPIQ SRQVNALMMT SGMYQNAGEF 250
    AWRVGLPAKS GVGGGIVAIV PQEMAIAVWS PELDDAGNSL AGVALLEKLT 300
    QRMGRSVF 308
    Length:308
    Mass (Da):33,487
    Last modified:November 25, 2008 - v1
    Checksum:i6D640A68EFD96120
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI11603.1.
    RefSeqiYP_002238573.1. NC_011283.1.

    Genome annotation databases

    EnsemblBacteriaiACI11603; ACI11603; KPK_2743.
    GeneIDi6937720.
    KEGGikpe:KPK_2743.
    PATRICi20438894. VBIKlePne121904_2819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000964 Genomic DNA. Translation: ACI11603.1 .
    RefSeqi YP_002238573.1. NC_011283.1.

    3D structure databases

    ProteinModelPortali B5XQU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 507522.KPK_2743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI11603 ; ACI11603 ; KPK_2743 .
    GeneIDi 6937720.
    KEGGi kpe:KPK_2743.
    PATRICi 20438894. VBIKlePne121904_2819.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi MSIAVWS.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci KPNE507522:GI0B-2744-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
      Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
      PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 342.

    Entry informationi

    Entry nameiGLSA_KLEP3
    AccessioniPrimary (citable) accession number: B5XQU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3