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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei224 – 2241UniRule annotation
Active sitei226 – 2261UniRule annotation
Active sitei231 – 2311UniRule annotation
Active sitei404 – 4041UniRule annotation
Active sitei406 – 4061UniRule annotation
Active sitei411 – 4111UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-2121-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:KPK_2120
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Cardiolipin synthase APRO_1000098908Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini219 – 24628PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini399 – 42628PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.
OrthoDBiEOG6Q2ST0.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XQA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFYTVVNW LVILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSFGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEDNSPVA
110 120 130 140 150
ESLFKLCERR QGIGGVKGNQ LQLLTESDDV MQALIRDIQL ARHNIEMVFY
160 170 180 190 200
IWQPGGMADS VAESLMAAAR RGVHCRLMLD SAGSVAFFRS PWAAMMRNAG
210 220 230 240 250
IEVVEALKVN LMRVFLRRMD LRQHRKMVMI DNYIAYTGSM NMVDPRYFKQ
260 270 280 290 300
DSGVGQWIDL MARMEGPVAT SMGIVYSCDW EIETGKRILP PPPDVNIMPF
310 320 330 340 350
EEASGHTIHT IASGPGFPED LIHQALLTAA YAAKEHLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIILPR KNDSLLVGWA SRAFFTELLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLVIDDA GFGSDLAAVQ
460 470 480
DDYISRSRLL DARRWLKRPL WQRIVERLFY FFSPLL
Length:486
Mass (Da):54,841
Last modified:November 25, 2008 - v1
Checksum:iEEF66DF24FF708A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI07826.1.
RefSeqiWP_008804416.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI07826; ACI07826; KPK_2120.
KEGGikpe:KPK_2120.
PATRICi20437710. VBIKlePne121904_2231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI07826.1.
RefSeqiWP_008804416.1. NC_011283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI07826; ACI07826; KPK_2120.
KEGGikpe:KPK_2120.
PATRICi20437710. VBIKlePne121904_2231.

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.
OrthoDBiEOG6Q2ST0.

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-2121-MONOMER.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiCLSA_KLEP3
AccessioniPrimary (citable) accession number: B5XQA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.