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B5XQ82 (B5XQ82_KLEP3) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Name:alr_1 EMBL ACI11636.1
Ordered Locus Names:KPK_1986 EMBL ACI11636.1
OrganismKlebsiella pneumoniae (strain 342) [Complete proteome] [HAMAP] EMBL ACI11636.1
Taxonomic identifier507522 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site351Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2531Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1301Substrate By similarity HAMAP-Rule MF_01201
Binding site3011Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue351N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
B5XQ82 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 37D9B1B09CDB327A

FASTA35638,690
        10         20         30         40         50         60 
MTRPVVASID LLALRQNLQI VRRAAPGSRL WAVVKANAYG HGVARVWSAL SGADGFALLN 

        70         80         90        100        110        120 
LEEAILLREQ GWKGPILLLE GFFHADELAV LDQYRLTTSV HSNWQIKALQ QAKLRAPLDI 

       130        140        150        160        170        180 
YLKVNSGMNR LGFMPERVHT VWQQLRAISN VGEMTLMSHF AEAENPQGIV EPMRRIEQAA 

       190        200        210        220        230        240 
EGLDCPRSLA NSAATLWHPE AHFDWVRPGI VLYGASPSGQ WQDIANTGLK PVMTLRSEVI 

       250        260        270        280        290        300 
GVQNLRPGEA IGYGGLYRTS QEQRIGIVAC GYADGYPRVA PSGTPVLVDG VRTTTVGRVS 

       310        320        330        340        350 
MDMLAVDLTP CPQAGIGAPV ELWGKEIKID DVAASSGTVG YELMCALAPR VPVVTL 

« Hide

References

[1]"Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 342 EMBL ACI11636.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000964 Genomic DNA. Translation: ACI11636.1.
RefSeqYP_002237825.1. NC_011283.1.

3D structure databases

ProteinModelPortalB5XQ82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING507522.KPK_1986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI11636; ACI11636; KPK_1986.
GeneID6939202.
KEGGkpe:KPK_1986.
PATRIC20437456. VBIKlePne121904_2106.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
OMAPVELWGQ.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycKPNE507522:GI0B-1987-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5XQ82_KLEP3
AccessionPrimary (citable) accession number: B5XQ82
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)