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Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-1865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
Gene namesi
Name:dcyDUniRule annotation
Ordered Locus Names:KPK_1864
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000001734 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328D-cysteine desulfhydrasePRO_1000136164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB5XPW3.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2515.
HOGENOMiHOG000022459.
KOiK05396.
OMAiWVPHEDA.
OrthoDBiEOG6FBX0P.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XPW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQNLTRFP RLELIGAPTP LEYLPRLSDH LGREIFIKRD DTTPLAMGGN
60 70 80 90 100
KLRKLEFLAA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE
110 120 130 140 150
NPIGTGAENY LSNGNRLLLD LFNTQVEMCD ALTNPAEQLD ELATRIEAQG
160 170 180 190 200
YRPYVIPVGG SNALGALGYV ESALEIAQQC EGAVEISSVV VASGSAGTHA
210 220 230 240 250
GLAVGLEQLM PQAELIGVTV SRSVADQLPK VVALQQAVAN SLELQAKADI
260 270 280 290 300
TLWDDYFAPG YGTPNEEGMA AVKLLAQLEG ILLDPVYTGK AMAGLIDGIT
310 320
QKRFKDEGPI LFVHTGGAPA LFAYHPHL
Length:328
Mass (Da):34,844
Last modified:November 25, 2008 - v1
Checksum:i59A8CEF33749C237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06739.1.
RefSeqiWP_012541230.1. NC_011283.1.
YP_002237706.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI06739; ACI06739; KPK_1864.
KEGGikpe:KPK_1864.
PATRICi20437222. VBIKlePne121904_1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06739.1.
RefSeqiWP_012541230.1. NC_011283.1.
YP_002237706.1. NC_011283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB5XPW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI06739; ACI06739; KPK_1864.
KEGGikpe:KPK_1864.
PATRICi20437222. VBIKlePne121904_1992.

Phylogenomic databases

eggNOGiCOG2515.
HOGENOMiHOG000022459.
KOiK05396.
OMAiWVPHEDA.
OrthoDBiEOG6FBX0P.

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-1865-MONOMER.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiDCYD_KLEP3
AccessioniPrimary (citable) accession number: B5XPW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: June 24, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.