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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Klebsiella pneumoniae (strain 342)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosyl-L-methionineUniRule annotation
Binding sitei64 – 641S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei85 – 851S-adenosyl-L-methionineUniRule annotation
Binding sitei129 – 1291S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciKPNE507522:GI0B-1511-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:KPK_1510
OrganismiKlebsiella pneumoniae (strain 342)
Taxonomic identifieri507522 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000001734 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Ubiquinone biosynthesis O-methyltransferasePRO_1000199687Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB5XNZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000278065.
KOiK00568.
OMAiHDWEKFV.
OrthoDBiEOG6D5G4H.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAEKTSVAP NVDHAEIAKF EAVASRWWDL EGEFKPLHRI NPLRLGYIAE
60 70 80 90 100
RSGGLFGKKV LDVGCGGGIL AESMAREGAT VTGLDMGAEP LQVAKLHALE
110 120 130 140 150
SGIQVDYVQE TVEEHAAKHP QQYDVVTCME MLEHVPDPQS VVHACARLVK
160 170 180 190 200
PGGQVFFSTI NRNGKAWLMA VVGAEYVMKM VPKGTHDVKK FIKPAELLSW
210 220 230 240
VDQTTLKEQH IIGLHYNPLT NTFKLAPGVD VNYMLHTTAK QD
Length:242
Mass (Da):26,653
Last modified:November 25, 2008 - v1
Checksum:i24E6393CFB79B579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06549.1.
RefSeqiWP_008803973.1. NC_011283.1.

Genome annotation databases

EnsemblBacteriaiACI06549; ACI06549; KPK_1510.
KEGGikpe:KPK_1510.
PATRICi20436549. VBIKlePne121904_1662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000964 Genomic DNA. Translation: ACI06549.1.
RefSeqiWP_008803973.1. NC_011283.1.

3D structure databases

ProteinModelPortaliB5XNZ3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI06549; ACI06549; KPK_1510.
KEGGikpe:KPK_1510.
PATRICi20436549. VBIKlePne121904_1662.

Phylogenomic databases

HOGENOMiHOG000278065.
KOiK00568.
OMAiHDWEKFV.
OrthoDBiEOG6D5G4H.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciKPNE507522:GI0B-1511-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice."
    Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H., Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y., Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W., Methe B.A.
    PLoS Genet. 4:E1000141-E1000141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 342.

Entry informationi

Entry nameiUBIG_KLEP3
AccessioniPrimary (citable) accession number: B5XNZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.