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B5XML5

- PROA_STRPZ

UniProt

B5XML5 - PROA_STRPZ

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Short name:
    GSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotation
    Ordered Locus Names:Spy49_1295c
    OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)
    Taxonomic identifieri471876 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001039: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Gamma-glutamyl phosphate reductasePRO_1000193664Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi471876.Spy49_1295c.

    Structurei

    3D structure databases

    ProteinModelPortaliB5XML5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0014.
    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiALTSYKW.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5XML5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDMRRLGQR AKQASLLIAP LSTQIKNRFL STLAKALVDD TQTLLAANQK    50
    DLANAKEHGI SDIMMDRLRL TSERIKAMAQ GVQQVADLAD PIGQVIKGYT 100
    NLDGLKILQK RVPLGVIAMI FESRPNVSVD AFSLAFKTNN AIILRGGKDA 150
    LHSNKALVKL IRQSLEKSGI TPDAVQLVED PSHAVAEELM QATDYVDVLI 200
    PRGGAKLIQT VKEKAKVPVI ETGVGNVHIY VDAQADLDMA TKIVINAKTK 250
    RPSVCNAAEG LVIHEAVAAR FIPMLEKAIN QVQPVEWRAD DKALPLFEQA 300
    VPAKAEDFET EFLDYIMSVK VVSSLEEAIF WINQHTSHHS EAIITRDIKV 350
    AETFQDLVDA AAVYVNASTR FTDGFVFGLG AEIGISTQKM HARGPMGLEA 400
    LTSTKFYING DGHIRE 416
    Length:416
    Mass (Da):45,528
    Last modified:November 25, 2008 - v1
    Checksum:iEA319F1B55B077E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000829 Genomic DNA. Translation: ACI61577.1.
    RefSeqiWP_009880775.1. NC_011375.1.
    YP_002286272.1. NC_011375.1.

    Genome annotation databases

    EnsemblBacteriaiACI61577; ACI61577; Spy49_1295c.
    GeneIDi6984601.
    KEGGisoz:Spy49_1295c.
    PATRICi19757682. VBIStrPyo129711_1337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000829 Genomic DNA. Translation: ACI61577.1 .
    RefSeqi WP_009880775.1. NC_011375.1.
    YP_002286272.1. NC_011375.1.

    3D structure databases

    ProteinModelPortali B5XML5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471876.Spy49_1295c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI61577 ; ACI61577 ; Spy49_1295c .
    GeneIDi 6984601.
    KEGGi soz:Spy49_1295c.
    PATRICi 19757682. VBIStrPyo129711_1337.

    Phylogenomic databases

    eggNOGi COG0014.
    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi ALTSYKW.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
      McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
      J. Bacteriol. 190:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NZ131.

    Entry informationi

    Entry nameiPROA_STRPZ
    AccessioniPrimary (citable) accession number: B5XML5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3