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B5XMJ4

- LUXS_STRPZ

UniProt

B5XMJ4 - LUXS_STRPZ

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Protein
S-ribosylhomocysteine lyase
Gene
luxS, Spy49_1273
Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron By similarity
Metal bindingi61 – 611Iron By similarity
Metal bindingi127 – 1271Iron By similarity

GO - Molecular functioni

  1. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:Spy49_1273
OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)
Taxonomic identifieri471876 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001039: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160S-ribosylhomocysteine lyaseUniRule annotation
PRO_1000093333Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471876.Spy49_1273.

Structurei

3D structure databases

ProteinModelPortaliB5XMJ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040372.
KOiK07173.
OMAiRDHLNSD.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XMJ4-1 [UniParc]FASTAAdd to Basket

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MTKEVIVESF ELDHTIVKAP YVRLISEEFG PKGDRITNFD VRLVQPNQNS    50
IETAGLHTIE HLLAKLIRQR IDGMIDCSPF GCRTGFHLIM WGKHSSTDIA 100
KVIKSSLEEI ATGITWEDVP GTTLESCGNY KDHSLFAAKE WAQLIIDQGI 150
SDDPFSRHVI 160
Length:160
Mass (Da):17,979
Last modified:November 25, 2008 - v1
Checksum:iA45592396C76BD21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI61556.1.
RefSeqiYP_002286251.1. NC_011375.1.

Genome annotation databases

EnsemblBacteriaiACI61556; ACI61556; Spy49_1273.
GeneIDi6984514.
KEGGisoz:Spy49_1273.
PATRICi19757636. VBIStrPyo129711_1314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI61556.1 .
RefSeqi YP_002286251.1. NC_011375.1.

3D structure databases

ProteinModelPortali B5XMJ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471876.Spy49_1273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI61556 ; ACI61556 ; Spy49_1273 .
GeneIDi 6984514.
KEGGi soz:Spy49_1273.
PATRICi 19757636. VBIStrPyo129711_1314.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040372.
KOi K07173.
OMAi RDHLNSD.
OrthoDBi EOG68WRBM.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
    McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
    J. Bacteriol. 190:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ131.

Entry informationi

Entry nameiLUXS_STRPZ
AccessioniPrimary (citable) accession number: B5XMJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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