B5XMF0 (AROE_STRPZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Spy49_1225c

Organism

Streptococcus pyogenes serotype M49 (strain NZ131) [Complete proteome] [HAMAP]

Taxonomic identifier

471876 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100147
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	73	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B5XMF0 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: FB84184D3E9610D7	FASTA	292	31,276
	10 20 30 40 50 60 MSERLSGHTL LVSLLATPIR HSLSPKMHNE AYAKLGLDYA YLAFEVGTEQ LADAVQGIRA 70 80 90 100 110 120 LGIRGSNVSM PNKEAILPLL DDLSPAAELV GAVNTVVNKD GKGHLVGHIT DGIGALRALA 130 140 150 160 170 180 DEGVSVKNKI ITLAGVGGAG KAIAVQLAFD GAKEVRLFNR QATRLSSVQK LVTKLNQLTR 190 200 210 220 230 240 TKVTLQDLED QTAFKEAIRE SHLFIDATSV GMKPLENLSL ITDPELIRPD LVVFDIVYSP 250 260 270 280 290 AETKLLAFAR QHGAQKVING LGMVLYQGAE AFKLITGQDM PVDAIKPLLG DE

References

[1]

"Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes." McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J. J. Bacteriol. 190:7773-7785(2008) [PubMed: 18820018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NZ131.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000829 Genomic DNA. Translation: ACI61512.1.
RefSeq	YP_002286207.1. NC_011375.1.
3D structure databases
ProteinModelPortal	B5XMF0.
ModBase	Search...
Protein-protein interaction databases
STRING	B5XMF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000049099; EBSTRP00000058882; EBSTRG00000049091.
GeneID	6984460.
GenomeReviews	Gene locus Spy49_1225c in contig CP000829_GR.
KEGG	soz:Spy49_1225c.
PATRIC	19757520. VBIStrPyo129711_1266.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027337.
HOGENOM	HBG553408.
OMA	SIYIDAT.
ProtClustDB	CLSK698780.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STRPZ

Accession

Primary (citable) accession number: B5XMF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program