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B5XKH9

- B5XKH9_STRPZ

UniProt

B5XKH9 - B5XKH9_STRPZ

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Protein

Phosphoenolpyruvate carboxylase

Gene
ppc, Spy49_0513
Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501 By similarityUniRule annotation
Active sitei595 – 5951 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:Spy49_0513Imported
OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)Imported
Taxonomic identifieri471876 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001039: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471876.Spy49_0513.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiELSTISC.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5XKH9-1 [UniParc]FASTAAdd to Basket

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MIEETSKEGD GHLPLKKLES SNNQAIIAEE VALLKEMLGN ITRRMIGDDA    50
FTVIESIMVL SEKQDYIELE KVIANISNQE MEVISRYFSI LPLLINISED 100
VDLAYEINHQ NNTDTDYLGK LALTIKDLAG KDNGKDILEQ VNVVPVLTAH 150
PTQVQRKTIL ELTTHIHKLL RKYRDAKAGV INLEKWRQEL YRYIEMIMQT 200
DIIREKKLQV KNEIKNVMQY YDGSLIQAVT KLTTEYKNLA QKHGLELDNP 250
KPITMGMWIG GDRDGNPFVT AETLCLSATV QSEVILNYYI DKLAALYRTF 300
SLSSTLVQPN SEVERLASLS QDQSIYRGNE PYRRAFHYIQ SRLKQTQIQL 350
TNQPAARMSS SVGLNTSAWP SPASLENPIL AYDSPVDFKA DLKAIEQSLL 400
DNGNSALIEG DLREVMQAVD IFGFFLASID MRQDSSVQEA CVAELLKGAN 450
IVDDYSSLSE TEKCDVLVQQ LMEEPRTLSS AAVAKSDLLE KELAIYTTAR 500
ELKDKLGEEV IKQHIISHTE SVSDMFELAI MLKEVGLVDQ QRARVQIVPL 550
FETIEDLDNA RDIMAAYLSH DIVKSWIATN RNYQEIMLGY SDSNKDGGYL 600
ASGWTLYKAQ NELTAIGEEH GVKITFFHGR GGTVGRGGGP SYDAITSQPF 650
GSIKDRIRLT EQGEIIENKY GNKDVAYYHL EMLISASINR MVTQMITDPN 700
EIDSFREIMD SIVADSNTIY RKLVFDNPHF YDYFFEASPI KEVSSLNIGS 750
RPAARKTITE ITGLRAIPWV FSWSQNRIMF PGWYGVGSAF KRYIDRAQGN 800
LERLQHMYQT WPFFHSLLSN VDMVLSKSNM NIAFQYAQLA ESQDVRDVFY 850
EILDEWQLTK NVILAIQDHD DLLEDNPSLK HSLKSRLPYF NVLNYIQIEL 900
IKRWRNNQLD ENDEKLIHTT INGIATGLRN SG 932
Length:932
Mass (Da):105,903
Last modified:November 25, 2008 - v1
Checksum:iB4A18ACB6C7A8BB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI60841.1.
RefSeqiWP_012560551.1. NC_011375.1.
YP_002285536.1. NC_011375.1.

Genome annotation databases

EnsemblBacteriaiACI60841; ACI60841; Spy49_0513.
GeneIDi6985528.
KEGGisoz:Spy49_0513.
PATRICi19756049. VBIStrPyo129711_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI60841.1 .
RefSeqi WP_012560551.1. NC_011375.1.
YP_002285536.1. NC_011375.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471876.Spy49_0513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI60841 ; ACI60841 ; Spy49_0513 .
GeneIDi 6985528.
KEGGi soz:Spy49_0513.
PATRICi 19756049. VBIStrPyo129711_0537.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ELSTISC.
OrthoDBi EOG6TJ7T8.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
    McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
    J. Bacteriol. 190:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ131Imported.

Entry informationi

Entry nameiB5XKH9_STRPZ
AccessioniPrimary (citable) accession number: B5XKH9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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