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B5XJ77

- SYR_STRPZ

UniProt

B5XJ77 - SYR_STRPZ

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Spy49_1762
OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)
Taxonomic identifieri471876 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001039: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Arginine--tRNA ligasePRO_1000095414Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi471876.Spy49_1762.

Structurei

3D structure databases

ProteinModelPortaliB5XJ77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi121 – 13111"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiYVKFHDE.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XJ77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTKTLIASE IAKVVPELEQ DAIFNLLETP KNSDMGDLAF PAFSLAKVLR
60 70 80 90 100
KAPQMIASEL AEQIDESQFE KVVAVGPYIN FFLDKVKISS QVLEQVITAG
110 120 130 140 150
SDYAQQDEGQ GRNVAIDMSS PNIAKPFSIG HLRSTVIGDS LANIFAKMGY
160 170 180 190 200
QPVKINHLGD WGKQFGMLIV AYKKWGDEAA VQAHPIDELL KLYVRINAEA
210 220 230 240 250
EIDPTVDEEA REWFRKLEDG DKEATELWQW FRDESLLEFN RLYDQLHVTF
260 270 280 290 300
DSYNGEAFYN DKMDEVLALL EAKNLLVESK GAQVVTLEKY GIAPPPLIKK
310 320 330 340 350
SDGATLHITR ALAPALYRKR TYDFAKSVYV VGNEQAAHFK QLKAVLKEMG
360 370 380 390 400
YDWSDDMTHV AFGLVTKGGA KLSTRKGNVI LLEPTVAEAI NRAASQIEAK
410 420 430 440 450
NPNLADKEAV AHAVGVGAIK FYDLKTDRMN GYDFDLEAMV SFEGETGPYV
460 470 480 490 500
QYAHARIQSI LRKADFTPSA TTTYSLADAE SWEIIKLIQD FPRIIKRTSD
510 520 530 540 550
NFEPSIMAKF AINLAQSFNK YYAHTRILDD NSERDNRLVL CYATATVLKE
560
ALRLLGVDAP NEM
Length:563
Mass (Da):62,993
Last modified:November 25, 2008 - v1
Checksum:i98E9A71AF85A13C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI62011.1.
RefSeqiWP_012561076.1. NC_011375.1.
YP_002286706.1. NC_011375.1.

Genome annotation databases

EnsemblBacteriaiACI62011; ACI62011; Spy49_1762.
GeneIDi6985445.
KEGGisoz:Spy49_1762.
PATRICi19758670. VBIStrPyo129711_1821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000829 Genomic DNA. Translation: ACI62011.1 .
RefSeqi WP_012561076.1. NC_011375.1.
YP_002286706.1. NC_011375.1.

3D structure databases

ProteinModelPortali B5XJ77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471876.Spy49_1762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI62011 ; ACI62011 ; Spy49_1762 .
GeneIDi 6985445.
KEGGi soz:Spy49_1762.
PATRICi 19758670. VBIStrPyo129711_1821.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247211.
KOi K01887.
OMAi YVKFHDE.
OrthoDBi EOG6JB13C.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
    McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
    J. Bacteriol. 190:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ131.

Entry informationi

Entry nameiSYR_STRPZ
AccessioniPrimary (citable) accession number: B5XJ77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3