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B5XJ18

- PUR5_STRPZ

UniProt

B5XJ18 - PUR5_STRPZ

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Spy49_0023
    OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)
    Taxonomic identifieri471876 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001039: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193050Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi471876.Spy49_0023.

    Structurei

    3D structure databases

    ProteinModelPortaliB5XJ18.
    SMRiB5XJ18. Positions 15-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5XJ18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKNAYAKS GVDVEAGYEV VERIKKHVAR TERAGVMGVL GGFGGMFDLS    50
    KTGVKEPVLV SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE 100
    PLYFLDYIAT GKNNPVKLEE VVSGVAEGCV QAGVALIGGE TAEMPGMYGE 150
    DDYDLAGFAV GVAEKSQIID GSKVKEGDIL LGLASSGIHS NGYSLVRRVF 200
    ADYTGKELLP ELEGKQLKDV LLEPTRIYVK AALPLIKEEL VNGIGHITGG 250
    GFIENVPRMF ADDLAAEIDE DKVPVLPIFK ALEKYGDIKH EEMFEIFNMG 300
    VGLMLAVSPE NVNRVKELLD EPVYEIGRII KKADASVVIK 340
    Length:340
    Mass (Da):36,500
    Last modified:November 25, 2008 - v1
    Checksum:i4E6B4A75CB1BB1A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000829 Genomic DNA. Translation: ACI60386.1.
    RefSeqiWP_009880322.1. NC_011375.1.
    YP_002285081.1. NC_011375.1.

    Genome annotation databases

    EnsemblBacteriaiACI60386; ACI60386; Spy49_0023.
    GeneIDi6984571.
    KEGGisoz:Spy49_0023.
    PATRICi19754979. VBIStrPyo129711_0025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000829 Genomic DNA. Translation: ACI60386.1 .
    RefSeqi WP_009880322.1. NC_011375.1.
    YP_002285081.1. NC_011375.1.

    3D structure databases

    ProteinModelPortali B5XJ18.
    SMRi B5XJ18. Positions 15-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471876.Spy49_0023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI60386 ; ACI60386 ; Spy49_0023 .
    GeneIDi 6984571.
    KEGGi soz:Spy49_0023.
    PATRICi 19754979. VBIStrPyo129711_0025.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
      McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
      J. Bacteriol. 190:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NZ131.

    Entry informationi

    Entry nameiPUR5_STRPZ
    AccessioniPrimary (citable) accession number: B5XJ18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3