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Protein

GTP-sensing transcriptional pleiotropic repressor CodY

Gene

codY

Organism
Streptococcus pyogenes serotype M49 (strain NZ131)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi206 – 225H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-sensing transcriptional pleiotropic repressor CodYUniRule annotation
Gene namesi
Name:codYUniRule annotation
Ordered Locus Names:Spy49_1387c
OrganismiStreptococcus pyogenes serotype M49 (strain NZ131)
Taxonomic identifieri471876 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001039 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001304601 – 260GTP-sensing transcriptional pleiotropic repressor CodYAdd BLAST260

Expressioni

Gene expression databases

CollecTFiEXPREG_00000330.

Structurei

3D structure databases

ProteinModelPortaliB5XI03.
SMRiB5XI03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CodY family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000058075.
KOiK03706.
OMAiFPEEYNE.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPiMF_00621. HTH_type_CodY. 1 hit.
InterProiView protein in InterPro
IPR014154. CodY.
IPR029016. GAF_dom-like.
IPR010312. GTP_sensing_CodY_N.
IPR013198. GTP_sensing_HTH_CodY_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF06018. CodY. 1 hit.
PF08222. HTH_CodY. 1 hit.
PIRSFiPIRSF011572. GTP_sensing_CodY. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR02787. codY_Gpos. 1 hit.

Sequencei

Sequence statusi: Complete.

B5XI03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLLEKTRK ITSILQRSVD SLETELPYNT MASRLADIID CNACIINGGG
60 70 80 90 100
TLLGYAMKYK TNTDRVEEFF EAKQFPDTYV KAASRVYDTE ANLSVENELT
110 120 130 140 150
IFPVESKDTY PGGLTTIAPI YGGGMRLGSL IIWRNDNEFS DDDLILVEIS
160 170 180 190 200
STVVGIQLLN LQTENLEDTI RKQTAVNMAI NTLSYSEMKA VAAILGELDG
210 220 230 240 250
NEGRLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG MKGTYLKVIN
260
EGIFAKLKEF
Length:260
Mass (Da):28,634
Last modified:November 25, 2008 - v1
Checksum:i694301330092AAAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000829 Genomic DNA. Translation: ACI61665.1.
RefSeqiWP_002983278.1. NC_011375.1.

Genome annotation databases

EnsemblBacteriaiACI61665; ACI61665; Spy49_1387c.
KEGGisoz:Spy49_1387c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCODY_STRPZ
AccessioniPrimary (citable) accession number: B5XI03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families