B5XB27 (AFMID_SALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable arylformamidase
EC=3.5.1.9

Alternative name(s):
Kynurenine formamidase
Short name=KF

Gene names

Name:

afmid

Organism

Salmo salar (Atlantic salmon)

Taxonomic identifier

8030 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the AFMID family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Probable arylformamidase		PRO_0000361879
Sites
	Active site	153	1	By similarity
	Active site	236	1	By similarity
	Active site	269	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5XB27 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 8ABC38B02E85DF67	FASTA	294	32,682
	10 20 30 40 50 60 MSRWKDMNKD ELERQFSPSQ WSHRMSADDV IKSHVTALKE GTERARGLAQ TLLNVPYGEG 70 80 90 100 110 120 EGEKLDVYVP TTTSLDVPLV IYLHGGYWQF LSKEESGFMA VPLVHKGVVV VAVGYDIAPK 130 140 150 160 170 180 GNMDVMVSQV RRSVVSVIQQ YSHISGLYLC GHSAGAHLAA MILSTDWSQY SVTPQIKGAF 190 200 210 220 230 240 LVSGIYDLLP ILSTYVNEPL KMTEEVALRN SPSQLVPQLK LSSSNCDIVV AVAQNDSPEF 250 260 270 280 290 RKQSEDYYKA LESTEGLKVT LEDVPNTDHF NIIEQLVDGD YHLTQLLLKM MGKS

References

[1]

"Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome." Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M., Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S., Koop B.F. BMC Genomics 11:279-279(2010) [PubMed: 20433749] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT048246 mRNA. Translation: ACI68047.1.
RefSeq	NP_001134570.1. NM_001141098.2.
UniGene	Ssa.2978.
3D structure databases
ProteinModelPortal	B5XB27.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100196069.
Organism-specific databases
CTD	125061.
Phylogenomic databases
HOVERGEN	HBG100436.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AFMID_SALSA

Accession

Primary (citable) accession number: B5XB27

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 25, 2008
Last modified:	June 28, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program