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Protein

Galactocerebrosidase

Gene

galc

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.By similarity

Catalytic activityi

D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91SubstrateBy similarity1
Binding sitei133SubstrateBy similarity1
Binding sitei179SubstrateBy similarity1
Active sitei180Proton donor/acceptorBy similarity1
Active sitei256NucleophileBy similarity1
Binding sitei378SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processLipid degradation, Lipid metabolism, Sphingolipid metabolism

Protein family/group databases

CAZyiGH59 Glycoside Hydrolase Family 59

Names & Taxonomyi

Protein namesi
Recommended name:
Galactocerebrosidase (EC:3.2.1.46)
Short name:
GALCERase
Alternative name(s):
Galactosylceramidase
Gene namesi
Name:galc
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
Proteomesi
  • UP000087266 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000037071423 – 666GalactocerebrosidaseAdd BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 376By similarity
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB5X3C1
SMRiB5X3C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 59 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01202

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001286 Glyco_hydro_59
IPR035394 Glyco_hydro_59_dom
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR15172 PTHR15172, 1 hit
PfamiView protein in Pfam
PF02057 Glyco_hydro_59, 1 hit
PF17387 Glyco_hydro_59M, 1 hit
PRINTSiPR00850 GLHYDRLASE59
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5X3C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYKLYFAIA LCFSLCFDLC IAESYVLDDK VGLGRTFDGI GGLSGGGATS
60 70 80 90 100
RLLVNYAEPY RSQILDYLFK PNFGASLHIL KVEIGGDAQT TDGTEPSHMH
110 120 130 140 150
YENDENFFRG YEWWLMREAK KRNPNITLIG LPWAFPGWVG HGKNWPYDFP
160 170 180 190 200
DITASYVVSW ILGAKHYHDL NIDYVGIWNE RNFDSKYIKL LRYTLDKSGL
210 220 230 240 250
ERVRIIASDN LWQPITYSLC VDQELADAVD VIGAHYPGTT TVIEALKTQK
260 270 280 290 300
KLWSSEDYST FNDEVGGGCW ARILNQNYVN GLMTATISWN LVASYYEDLP
310 320 330 340 350
FGRDGLMTAE EPWTGNYVVE SPIWITAHTT QFSQPGWTYL QTVGHLVHGG
360 370 380 390 400
SYVALTDSNG NLTVVIETMT HDHSVCIRPP LLPFNVTAQN VTFQLKGSFA
410 420 430 440 450
LIKELQVWQS RFDFKTKKPF FFKKLSPLKI SDGSFTLSLD VDEVYTLTTI
460 470 480 490 500
STGLKGTYPD PPTSGPFPKV YFDDFNVANP SFSEAPDFAD QTGVFEYYIN
510 520 530 540 550
LTDPGPHVFT LRQVVTQMPV TWATDADQTI SVIGDYKWQN LTVTCDVFME
560 570 580 590 600
TVKTGGVFIA ARVDKGGQSV RSAKGVFFWV FADGSYKVTN DLVGKTVLAE
610 620 630 640 650
GLSGTRAYGW HTLTLTVEGQ YATGLLNGYP LWKDAVVLGP KNGWAAIGTH
660
SFELAQFDNF AVEAKL
Length:666
Mass (Da):74,494
Last modified:November 25, 2008 - v1
Checksum:i7169F6D7ADD8CA67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT045540 mRNA Translation: ACI33802.1
RefSeqiNP_001133732.1, NM_001140260.1
UniGeneiSsa.15050

Genome annotation databases

GeneIDi100195231
KEGGisasa:100195231

Similar proteinsi

Entry informationi

Entry nameiGALC_SALSA
AccessioniPrimary (citable) accession number: B5X3C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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