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Protein

GTPase Era, mitochondrial

Gene

eral1

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 122GTPSequence analysis8
Nucleotide bindingi162 – 166GTPSequence analysis5
Nucleotide bindingi231 – 234GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase Era, mitochondrial
Alternative name(s):
ERA-like protein 1
Gene namesi
Name:eral1
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
Proteomesi
  • UP000087266 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000040454919 – 457GTPase Era, mitochondrialAdd BLAST439

Structurei

3D structure databases

ProteinModelPortaliB5X2B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 350Era-type GAdd BLAST244
Domaini376 – 457KH type-2Add BLAST82

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051495.
KOiK03595.

Family and domain databases

CDDicd04163. Era. 1 hit.
Gene3Di3.30.300.20. 1 hit.
HAMAPiMF_00367. GTPase_Era. 1 hit.
InterProiView protein in InterPro
IPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_sf_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
PfamiView protein in Pfam
PF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5X2B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRVSISTF GKSLRVRRVA NVSAPLANAS PFLRTGWAAR PPGTNNGHGF
60 70 80 90 100
RFTPACFITS DAFLSRLAKG KAETDDTHYH HPASVLPDSA EQLSLLVKDP
110 120 130 140 150
DQPENSKVLR VAIIGAPNAG KSTLSNQLLG RKVFAVSKKV HTTRARALGV
160 170 180 190 200
LTEDDTQIIL LDTPGLTTPT KVKRHQLEKS LLEDPWNTVK EAGLVVVMVD
210 220 230 240 250
VSDKWACNKL DFEVLKCLTQ HPDVPAVLVL NKVDLLKSKS RLLEITADLT
260 270 280 290 300
CGVVNGRKLQ VRRVIKPPWA ERRTDREART SGSGDEEKPG GDVADGEGSE
310 320 330 340 350
ALSGLSKEQL RALKTQQGWA HFKDVFMVSA VDGEDVETLK RYLVVGAKPG
360 370 380 390 400
SWQYHSDVLT DQTPEEICTN TVREKLLEYL PKEVPYTMTQ AIDLWHDREN
410 420 430 440 450
GELDIAVKLY VKKESHMKMV IGQAGQMVAR IAREAGDDLS TVFLREVKLR

LSVKVKN
Length:457
Mass (Da):50,510
Last modified:November 25, 2008 - v1
Checksum:i8FBFB32F3B9C7CC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT045187 mRNA. Translation: ACI33449.1.
BT059676 mRNA. Translation: ACN11389.1.
RefSeqiNP_001133545.1. NM_001140073.1.
UniGeneiSsa.32452.

Genome annotation databases

GeneIDi100195044.
KEGGisasa:100195044.

Similar proteinsi

Entry informationi

Entry nameiERAL1_SALSA
AccessioniPrimary (citable) accession number: B5X2B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 25, 2008
Last modified: November 22, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families