Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B5VMS9 (SDC25_YEAS6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide exchange factor SDC25
Gene names
Name:SDC25
Synonyms:SCD25
ORF Names:AWRI1631_120390
OrganismSaccharomyces cerevisiae (strain AWRI1631) (Baker's yeast) [Complete proteome]
Taxonomic identifier545124 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes the exchange of Ras-bound GDP by GTP By similarity.

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

Sequence similarities

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12651265Guanine nucleotide exchange factor SDC25
PRO_0000393438

Regions

Domain26 – 9772SH3
Domain782 – 914133N-terminal Ras-GEF
Domain952 – 1199248Ras-GEF

Sequences

Sequence LengthMass (Da)Tools
B5VMS9 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: CDD978493BB58024

FASTA1,265146,786
        10         20         30         40         50         60 
MSRTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SQNKLSLRVG DLIYVLTKGS 

        70         80         90        100        110        120 
NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH GVPEIGNELE IFQAGLNLKL 

       130        140        150        160        170        180 
ELSSNPVILS LEDFLDCCRD IEFKEQLAWS PIPVHERKGC CELLYYNQDL DVYCRTLPYL 

       190        200        210        220        230        240 
PQNQVETVND YSSFPAISKI AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER 

       250        260        270        280        290        300 
DLLANEREKF LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF 

       310        320        330        340        350        360 
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL TILPQLTPRF 

       370        380        390        400        410        420 
FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG IVAENNDEIP ASKQGTSCSS 

       430        440        450        460        470        480 
ETSHHSPSAP FQRRRRGTIF SNVPGSSDES DTIWSKRKKP YPLNEETLSL VRARKEQLDA 

       490        500        510        520        530        540 
KLKQMIKSAN EYLSNTANFS KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG 

       550        560        570        580        590        600 
DENRVFDEDV AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP 

       610        620        630        640        650        660 
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD PDSLILFHNL 

       670        680        690        700        710        720 
INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL ILERENLLNY AARMMKNNIT 

       730        740        750        760        770        780 
ELLLRGEEGY GSYDGGETAE KSDTNAVYAD SDTKDNDEWR DSQVKLPRYL QREYDSELIW 

       790        800        810        820        830        840 
GSNNRIKGGS KHALISYLTD NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED 

       850        860        870        880        890        900 
LCFEEYNEWV TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT 

       910        920        930        940        950        960 
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA VDPVLFATQL 

       970        980        990       1000       1010       1020 
TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS FANKLTNFIS YSIVKEADKS 

      1030       1040       1050       1060       1070       1080 
KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK 

      1090       1100       1110       1120       1130       1140 
LMDPKKNFIN YRSELKSLHS APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY 

      1150       1160       1170       1180       1190       1200 
INFNKRSRLV DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP 

      1210       1220       1230       1240       1250       1260 
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV SKQRRRMFDF 


LLSVD 

« Hide

References

[1]"Comparative genome analysis of a Saccharomyces cerevisiae wine strain."
Borneman A.R., Forgan A.H., Pretorius I.S., Chambers P.J.
FEMS Yeast Res. 8:1185-1195(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AWRI1631.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABSV01001554 Genomic DNA. Translation: EDZ70763.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG78WM2F.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDC25_YEAS6
AccessionPrimary (citable) accession number: B5VMS9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 25, 2008
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families