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Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Promotes the exchange of Ras-bound GDP by GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
ORF Names:AWRI1631_120390
OrganismiSaccharomyces cerevisiae (strain AWRI1631) (Baker's yeast)
Taxonomic identifieri545124 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000008988 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12651265Guanine nucleotide exchange factor SDC25PRO_0000393438Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9772SH3PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 914133N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini952 – 1199248Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5VMS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SQNKLSLRVG
60 70 80 90 100
DLIYVLTKGS NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH
110 120 130 140 150
GVPEIGNELE IFQAGLNLKL ELSSNPVILS LEDFLDCCRD IEFKEQLAWS
160 170 180 190 200
PIPVHERKGC CELLYYNQDL DVYCRTLPYL PQNQVETVND YSSFPAISKI
210 220 230 240 250
AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER DLLANEREKF
260 270 280 290 300
LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF
310 320 330 340 350
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL
360 370 380 390 400
TILPQLTPRF FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG
410 420 430 440 450
IVAENNDEIP ASKQGTSCSS ETSHHSPSAP FQRRRRGTIF SNVPGSSDES
460 470 480 490 500
DTIWSKRKKP YPLNEETLSL VRARKEQLDA KLKQMIKSAN EYLSNTANFS
510 520 530 540 550
KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG DENRVFDEDV
560 570 580 590 600
AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP
610 620 630 640 650
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD
660 670 680 690 700
PDSLILFHNL INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL
710 720 730 740 750
ILERENLLNY AARMMKNNIT ELLLRGEEGY GSYDGGETAE KSDTNAVYAD
760 770 780 790 800
SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS KHALISYLTD
810 820 830 840 850
NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV
860 870 880 890 900
TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT
910 920 930 940 950
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA
960 970 980 990 1000
VDPVLFATQL TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS
1010 1020 1030 1040 1050
FANKLTNFIS YSIVKEADKS KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS
1060 1070 1080 1090 1100
ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK LMDPKKNFIN YRSELKSLHS
1110 1120 1130 1140 1150
APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY INFNKRSRLV
1160 1170 1180 1190 1200
DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP
1210 1220 1230 1240 1250
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV
1260
SKQRRRMFDF LLSVD
Length:1,265
Mass (Da):146,786
Last modified:November 25, 2008 - v1
Checksum:iCDD978493BB58024
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSV01001554 Genomic DNA. Translation: EDZ70763.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSV01001554 Genomic DNA. Translation: EDZ70763.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genome analysis of a Saccharomyces cerevisiae wine strain."
    Borneman A.R., Forgan A.H., Pretorius I.S., Chambers P.J.
    FEMS Yeast Res. 8:1185-1195(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AWRI1631.

Entry informationi

Entry nameiSDC25_YEAS6
AccessioniPrimary (citable) accession number: B5VMS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 25, 2008
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.