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B5UKF4 (B5UKF4_BACCE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218 EMBL EDZ53895.1
ORF Names:BCAH1134_1136 EMBL EDZ53895.1
OrganismBacillus cereus AH1134 EMBL EDZ53895.1
Taxonomic identifier405533 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4. RuleBase RU000554

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region27 – 315Substrate binding By similarity HAMAP MF_00218

Sites

Binding site461Substrate By similarity HAMAP MF_00218
Binding site761Substrate By similarity HAMAP MF_00218
Binding site1521Substrate By similarity HAMAP MF_00218
Binding site2071Substrate By similarity HAMAP MF_00218
Binding site3201Substrate By similarity HAMAP MF_00218
Site761Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
B5UKF4 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 409BE98AEED4BB2C

FASTA34839,239
        10         20         30         40         50         60 
MVRTINETFL KACRGERTDY VPAWYMRQAG RSQPEYRKIK EKYSLFEITH NPELCAYVTK 

        70         80         90        100        110        120 
LPVDQYNVDA AILYKDIMSP LPAIGVDVEI KSGIGPVIDN PIRSLQDVEK LGEINPEDDV 

       130        140        150        160        170        180 
PYILDTIRLL TTEMLDVPLI GFSGAPFTLA SYMIEGGPSR NYHNTKAFMY AEPKAWFALM 

       190        200        210        220        230        240 
DKLADMVITY LKAQINAGAK AVQIFDSWVG TVNVADYRVF IKPAMERIFA EVRKMGVPMI 

       250        260        270        280        290        300 
MHGVGAAHLV NEWHDLPLDV VGLDWRLPIE EARARGVHKA VQGNMDPSFL LAPWSVIEEH 

       310        320        330        340 
VKGILDQGMK QPGYIFNLGH GVFPEVNPDT LKRLTTFIHE YSKGQLAK

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References

[1]"Genome sequence of Bacillus cereus AH1134."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Callegan M.C., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: AH1134 EMBL EDZ53895.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ABDA02000001 Genomic DNA. Translation: EDZ53895.1.

3D structure databases

ProteinModelPortalB5UKF4.
SMRB5UKF4. Positions 4-345.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC24774298. VBIBacCer51833_0751.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5UKF4_BACCE
AccessionPrimary (citable) accession number: B5UKF4
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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