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Protein

Voltage-dependent P/Q-type calcium channel subunit alpha

Gene

CACNA1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent P/Q-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1388. CACNA1A.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 119HelicalSequence analysisAdd BLAST18
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei222 – 245HelicalSequence analysisAdd BLAST24
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
Transmembranei488 – 507HelicalSequence analysisAdd BLAST20
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei614 – 636HelicalSequence analysisAdd BLAST23
Transmembranei690 – 714HelicalSequence analysisAdd BLAST25
Transmembranei1243 – 1262HelicalSequence analysisAdd BLAST20
Transmembranei1282 – 1303HelicalSequence analysisAdd BLAST22
Transmembranei1315 – 1332HelicalSequence analysisAdd BLAST18
Transmembranei1377 – 1399HelicalSequence analysisAdd BLAST23
Transmembranei1489 – 1514HelicalSequence analysisAdd BLAST26
Transmembranei1570 – 1588HelicalSequence analysisAdd BLAST19
Transmembranei1600 – 1623HelicalSequence analysisAdd BLAST24
Transmembranei1693 – 1711HelicalSequence analysisAdd BLAST19
Transmembranei1789 – 1813HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141837.
PharmGKBiPA26007.

PTM / Processingi

Proteomic databases

MaxQBiB5TYJ1.
PaxDbiB5TYJ1.
PeptideAtlasiB5TYJ1.
PRIDEiB5TYJ1.

Expressioni

Gene expression databases

ExpressionAtlasiB5TYJ1. baseline and differential.
GenevisibleiB5TYJ1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353362.

Structurei

3D structure databases

ProteinModelPortaliB5TYJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1950 – 1984Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili710 – 746Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR005448. CACNA1A.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF59. PTHR10037:SF59. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01632. PQVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5TYJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ
60 70 80 90 100
SMAQRARTMA LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF
110 120 130 140 150
EYMILATIIA NCIVLALEQH LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI
160 170 180 190 200
KIIALGFAFH KGSYLRNGWN VMDFVVVLTG ILATVGTEFD LRTLRAVRVL
210 220 230 240 250
RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG
260 270 280 290 300
KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
310 320 330 340 350
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF
360 370 380 390 400
MLNLVLGVLS GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE
410 420 430 440 450
EVILAEDETD GEQRHPFDGA LRRTTIKKSK TDLLNPEEAE DQLADIASVG
460 470 480 490 500
SPFARASIKS AKLENSTFFH KKERRMRFYI RRMVKTQAFY WTVLSLVALN
510 520 530 540 550
TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG LGTRPYFHSS
560 570 580 590 600
FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL
610 620 630 640 650
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN
660 670 680 690 700
FDTFPAAIMT VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF
710 720 730 740 750
GNYTLLNVFL AIAVDNLANA QELTKDEQEE EEAANQKLAL QKAKEVAEVS
760 770 780 790 800
PLSAANMSIA VKEQQKNQKP AKSVWEQRTS EMRKQNLLAS REALYNEMDP
810 820 830 840 850
DERWKAAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR AAEPTVDQRL
860 870 880 890 900
GQQRAEDFLR KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREGPYGR
910 920 930 940 950
ESDHHAREGS LEQPGFWEGE AERGKAGDPH RRHVHRQGGS RESRSGSPRT
960 970 980 990 1000
GADGEHRRHR AHRRPGEEGP EDKAERRARH REGSRPARGG EGEGEGPDGG
1010 1020 1030 1040 1050
ERRRRHRHGA PATYEGDARR EDKERRHRRR KENQGSGVPV SGPNLSTTRP
1060 1070 1080 1090 1100
IQQDLGRQDP PLAEDIDNMK NNKLATAESA APHGSLGHAG LPQSPAKMGN
1110 1120 1130 1140 1150
STDPGPMLAI PAMATNPQNA ASRRTPNNPG NPSNPGPPKT PENSLIVTNP
1160 1170 1180 1190 1200
SGTQTNSAKT ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKEE
1210 1220 1230 1240 1250
EKKEEEEDDR GEDGPKPMPP YSSMFILSTT NPLRRLCHYI LNLRYFEMCI
1260 1270 1280 1290 1300
LMVIAMSSIA LAAEDPVQPN APRNNVLRYF DYVFTGVFTF EMVIKMIDLG
1310 1320 1330 1340 1350
LVLHQGAYFR DLWNILDFIV VSGALVAFAF TGNSKGKDIN TIKSLRVLRV
1360 1370 1380 1390 1400
LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI LIVYMLFMFI FAVVAVQLFK
1410 1420 1430 1440 1450
GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE FHYDNVLWAL
1460 1470 1480 1490 1500
LTLFTVSTGE GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF
1510 1520 1530 1540 1550
FFVNIFVALI IITFQEQGDK MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ
1560 1570 1580 1590 1600
NKQSFQYRMW QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV
1610 1620 1630 1640 1650
FNIVFTSLFS LECVLKVMAF GILNYFRDAW NIFDFVTVLG SITDILVTEF
1660 1670 1680 1690 1700
GNPNNFINLS FLRLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL
1710 1720 1730 1740 1750
IAMLFFIYAI IGMQVFGNIG IDVEDEDSDE DEFQITEHNN FRTFFQALML
1760 1770 1780 1790 1800
LFRSATGEAW HNIMLSCLSG KPCDKNSGIL TRECGNEFAY FYFVSFIFLC
1810 1820 1830 1840 1850
SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEYVRVWAE YDPAAWGRMP
1860 1870 1880 1890 1900
YLDMYQMLRH MSPPLGLGKK CPARVAYKRL LRMDLPVADD NTVHFNSTLM
1910 1920 1930 1940 1950
ALIRTALDIK IAKGGADKQQ MDAELRKEMM AIWPNLSQKT LDLLVTPHKS
1960 1970 1980 1990 2000
TDLTVGKIYA AMMIMEYYRQ SKAKKLQAMR EEQDRTPLMF QRMEPPSPTQ
2010 2020 2030 2040 2050
EGGPGQNALP STQLDPGGAL MAHESGLKES PSWVTQRAQE MFQKTGTWSP
2060 2070 2080 2090 2100
EQGPPTDMPN SQPNSQSVEM REMGRDGYSD SEHYLPMEGQ GRAASMPRLP
2110 2120 2130 2140 2150
AENQRRRGRP RGNNLSTISD TSPMKRSASV LGPKARRLDD YSLERVPPEE
2160 2170 2180 2190 2200
NQRHHQRRRD RSHRASERSL GRYTDVDTGL GTDLSMTTQS GDLPSKERDQ
2210 2220 2230 2240 2250
ERGRPKDRKH RQHHHHHHHH HHPPPPDKDR YAQERPDHGR ARARDQRWSR
2260
SPSEGREHMA HRQ
Length:2,263
Mass (Da):257,143
Last modified:November 4, 2008 - v1
Checksum:iC331009AE19A1959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005305 Genomic DNA. No translation available.
AC005513 Genomic DNA. No translation available.
AC011446 Genomic DNA. No translation available.
AC022436 Genomic DNA. No translation available.
AC026805 Genomic DNA. No translation available.
AC093062 Genomic DNA. No translation available.
AC098781 Genomic DNA. No translation available.
AC124224 Genomic DNA. No translation available.
KF456505 Genomic DNA. No translation available.
FJ040507 mRNA. Translation: ACH89974.1.
RefSeqiNP_001167551.1. NM_001174080.1.
UniGeneiHs.501632.

Genome annotation databases

EnsembliENST00000636549; ENSP00000490578; ENSG00000141837.
GeneIDi773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005305 Genomic DNA. No translation available.
AC005513 Genomic DNA. No translation available.
AC011446 Genomic DNA. No translation available.
AC022436 Genomic DNA. No translation available.
AC026805 Genomic DNA. No translation available.
AC093062 Genomic DNA. No translation available.
AC098781 Genomic DNA. No translation available.
AC124224 Genomic DNA. No translation available.
KF456505 Genomic DNA. No translation available.
FJ040507 mRNA. Translation: ACH89974.1.
RefSeqiNP_001167551.1. NM_001174080.1.
UniGeneiHs.501632.

3D structure databases

ProteinModelPortaliB5TYJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353362.

Proteomic databases

MaxQBiB5TYJ1.
PaxDbiB5TYJ1.
PeptideAtlasiB5TYJ1.
PRIDEiB5TYJ1.

Protocols and materials databases

DNASUi773.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000636549; ENSP00000490578; ENSG00000141837.
GeneIDi773.

Organism-specific databases

CTDi773.
HGNCiHGNC:1388. CACNA1A.
OpenTargetsiENSG00000141837.
PharmGKBiPA26007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOVERGENiHBG050763.

Miscellaneous databases

ChiTaRSiCACNA1A. human.
GenomeRNAii773.

Gene expression databases

ExpressionAtlasiB5TYJ1. baseline and differential.
GenevisibleiB5TYJ1. HS.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR005448. CACNA1A.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF59. PTHR10037:SF59. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01632. PQVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB5TYJ1_HUMAN
AccessioniPrimary (citable) accession number: B5TYJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 4, 2008
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.