B5TKC0 (B5TKC0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Estrogen receptor alpha substantia nigra isoform EMBL ACH73261.1

Gene names

Name:

ESR1 EMBL ACH73261.1

Organism

Homo sapiens (Human) EMBL ACH73261.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001628
Cellular component	Nucleus SAAS SAAS001628
Domain	Zinc-finger SAAS SAAS008946
Ligand	DNA-binding SAAS SAAS008946 Metal-binding Zinc
Molecular function	Receptor EMBL ACH73261.1
Gene Ontology (GO)
Biological_process	steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: GOC transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ACH73261.1
	Non-terminal residue	140	1	EMBL ACH73261.1

Sequences

	Sequence		Length	Mass (Da)
	B5TKC0 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: C5188EBA52126212	FASTA	140	15,745
	10 20 30 40 50 60 ASGYHYGVWS CEGCKAFFKR SIQGHNDYMC PATNQCTIDK NRRKSCQACR LRKCYEVGMM 70 80 90 100 110 120 KGGIRKDRRG GRMLKHMSNK GMEHLYSMKC KNVVPLYDLL LEMLDAHRLH APTSRGGASV 130 140 EETDQSHLAT AGSTSSHSLQ

References

[1]	"Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain." Ishunina T.A., Swaab D.F. Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Substantia nigra EMBL ACH73261.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU982838 mRNA. Translation: ACH73261.1.
IPI	IPI00914588.
UniGene	Hs.208124.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR024736. Oestrogen-typ_rcpt_final_C_dom. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF12743. ESR1_C. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	B5TKC0.
ChiTaRS	ESR1. human.
NextBio	35478278.

Entry information

Entry name

B5TKC0_HUMAN

Accession

Primary (citable) accession number: B5TKC0

Entry history

Integrated into UniProtKB/TrEMBL:	November 4, 2008
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.