Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei446PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:DEHA2F22352g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome F

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 556LumenalSequence analysisAdd BLAST538
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Topological domaini578 – 684CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000041191919 – 684Pheromone-processing carboxypeptidase KEX1Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi606 – 611Poly-Glu6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
InParanoidiB5RUL7.
KOiK01288.
OMAiSYPACGS.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5RUL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIKYLLLIL VQSFVAFALP FTSRSDPKAE YLVTSLPGLY SNIRTDERPL
60 70 80 90 100
MFAGQLELYP ENQTHYFFWK YQDTNQIPEA KKRTIFWLNG GPGCSSMDGA
110 120 130 140 150
LMEAGPFRIN KEGEVIYNEG SWHKSGDMVF VDQPAGTGFS YSDDYDHDLD
160 170 180 190 200
QITVEFVRFM EKFFELFPED ASNEIYFAGE SYAGQYIPYI ADGILRRNKN
210 220 230 240 250
LREGEKPFNL KGLMIGNGWI APNEQSLSYL PYSVQAGIIK TNNPRWSSIL
260 270 280 290 300
RQHQECQDIV SENDGPDGSD VSQVVSNTCE RVLNLILEAT RDQSAADNEQ
310 320 330 340 350
CVNMYDHTLR DSYPSCGMNW PPDLANVTPF LREQSVMNDL NLINHKKWSE
360 370 380 390 400
CSGKVGNSFR AKNSKPAIHL FPSILEEIPI MLFNGNRDII CNYIGIEGFI
410 420 430 440 450
KKLTWNGQTG FSEDLDTLDW VYDNKTAGYI QSERNLTVVN VFDASHMVPF
460 470 480 490 500
DKPEISRSLI DIITGNFDEK EVDNKSDMKK KSIVTYPLGV RMAKQKEESE
510 520 530 540 550
SKTSPTSVTQ SKTSSISAVS GKSLATSTTL DQEHSATPSA EAERAKNQQT
560 570 580 590 600
SNRITRLIQL LVIVVLIWGV YILYSSYRSR PSSIIKTGPS GKKKNVQWAD
610 620 630 640 650
QLRQFEEEEI EQNEQGILSR ALNKLKGGDS RGTYAPTSGK TYEDIEMNEG
660 670 680
ITEHTDNRVD DFIIESDEED AHDENQTNKQ SVSK
Length:684
Mass (Da):77,336
Last modified:November 4, 2008 - v1
Checksum:i8254AE19456BE382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAR66395.1.
RefSeqiXP_002770877.1. XM_002770831.1.

Genome annotation databases

EnsemblFungiiCAR66395; CAR66395; DEHA2F22352g.
GeneIDi8999041.
KEGGidha:DEHA2F22352g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382138 Genomic DNA. Translation: CAR66395.1.
RefSeqiXP_002770877.1. XM_002770831.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAR66395; CAR66395; DEHA2F22352g.
GeneIDi8999041.
KEGGidha:DEHA2F22352g.

Phylogenomic databases

HOGENOMiHOG000208879.
InParanoidiB5RUL7.
KOiK01288.
OMAiSYPACGS.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_DEBHA
AccessioniPrimary (citable) accession number: B5RUL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 4, 2008
Last modified: September 7, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.