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B5RUL7

- KEX1_DEBHA

UniProt

B5RUL7 - KEX1_DEBHA

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei181 – 1811PROSITE-ProRule annotation
    Active sitei388 – 3881PROSITE-ProRule annotation
    Active sitei446 – 4461PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:DEHA2F22352g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome F

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 684666Pheromone-processing carboxypeptidase KEX1PRO_0000411919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.B5RUL7.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 556538LumenalSequence AnalysisAdd
    BLAST
    Topological domaini578 – 684107CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei557 – 57721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi606 – 6116Poly-Glu

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiCERAINI.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B5RUL7-1 [UniParc]FASTAAdd to Basket

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    MVIKYLLLIL VQSFVAFALP FTSRSDPKAE YLVTSLPGLY SNIRTDERPL    50
    MFAGQLELYP ENQTHYFFWK YQDTNQIPEA KKRTIFWLNG GPGCSSMDGA 100
    LMEAGPFRIN KEGEVIYNEG SWHKSGDMVF VDQPAGTGFS YSDDYDHDLD 150
    QITVEFVRFM EKFFELFPED ASNEIYFAGE SYAGQYIPYI ADGILRRNKN 200
    LREGEKPFNL KGLMIGNGWI APNEQSLSYL PYSVQAGIIK TNNPRWSSIL 250
    RQHQECQDIV SENDGPDGSD VSQVVSNTCE RVLNLILEAT RDQSAADNEQ 300
    CVNMYDHTLR DSYPSCGMNW PPDLANVTPF LREQSVMNDL NLINHKKWSE 350
    CSGKVGNSFR AKNSKPAIHL FPSILEEIPI MLFNGNRDII CNYIGIEGFI 400
    KKLTWNGQTG FSEDLDTLDW VYDNKTAGYI QSERNLTVVN VFDASHMVPF 450
    DKPEISRSLI DIITGNFDEK EVDNKSDMKK KSIVTYPLGV RMAKQKEESE 500
    SKTSPTSVTQ SKTSSISAVS GKSLATSTTL DQEHSATPSA EAERAKNQQT 550
    SNRITRLIQL LVIVVLIWGV YILYSSYRSR PSSIIKTGPS GKKKNVQWAD 600
    QLRQFEEEEI EQNEQGILSR ALNKLKGGDS RGTYAPTSGK TYEDIEMNEG 650
    ITEHTDNRVD DFIIESDEED AHDENQTNKQ SVSK 684
    Length:684
    Mass (Da):77,336
    Last modified:November 4, 2008 - v1
    Checksum:i8254AE19456BE382
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAR66395.1.
    RefSeqiXP_002770877.1. XM_002770831.1.

    Genome annotation databases

    GeneIDi8999041.
    KEGGidha:DEHA2F22352g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382138 Genomic DNA. Translation: CAR66395.1 .
    RefSeqi XP_002770877.1. XM_002770831.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.B5RUL7.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8999041.
    KEGGi dha:DEHA2F22352g.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi CERAINI.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiKEX1_DEBHA
    AccessioniPrimary (citable) accession number: B5RUL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3