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B5RUL7

- KEX1_DEBHA

UniProt

B5RUL7 - KEX1_DEBHA

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, DEHA2F22352g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811 By similarity
Active sitei388 – 3881 By similarity
Active sitei446 – 4461 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:DEHA2F22352g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome F

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 556538Lumenal Reviewed predictionAdd
BLAST
Transmembranei557 – 57721Helical; Reviewed predictionAdd
BLAST
Topological domaini578 – 684107Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 684666Pheromone-processing carboxypeptidase KEX1PRO_0000411919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi424 – 4241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4959.B5RUL7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi606 – 6116Poly-Glu

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiCERAINI.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5RUL7-1 [UniParc]FASTAAdd to Basket

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MVIKYLLLIL VQSFVAFALP FTSRSDPKAE YLVTSLPGLY SNIRTDERPL    50
MFAGQLELYP ENQTHYFFWK YQDTNQIPEA KKRTIFWLNG GPGCSSMDGA 100
LMEAGPFRIN KEGEVIYNEG SWHKSGDMVF VDQPAGTGFS YSDDYDHDLD 150
QITVEFVRFM EKFFELFPED ASNEIYFAGE SYAGQYIPYI ADGILRRNKN 200
LREGEKPFNL KGLMIGNGWI APNEQSLSYL PYSVQAGIIK TNNPRWSSIL 250
RQHQECQDIV SENDGPDGSD VSQVVSNTCE RVLNLILEAT RDQSAADNEQ 300
CVNMYDHTLR DSYPSCGMNW PPDLANVTPF LREQSVMNDL NLINHKKWSE 350
CSGKVGNSFR AKNSKPAIHL FPSILEEIPI MLFNGNRDII CNYIGIEGFI 400
KKLTWNGQTG FSEDLDTLDW VYDNKTAGYI QSERNLTVVN VFDASHMVPF 450
DKPEISRSLI DIITGNFDEK EVDNKSDMKK KSIVTYPLGV RMAKQKEESE 500
SKTSPTSVTQ SKTSSISAVS GKSLATSTTL DQEHSATPSA EAERAKNQQT 550
SNRITRLIQL LVIVVLIWGV YILYSSYRSR PSSIIKTGPS GKKKNVQWAD 600
QLRQFEEEEI EQNEQGILSR ALNKLKGGDS RGTYAPTSGK TYEDIEMNEG 650
ITEHTDNRVD DFIIESDEED AHDENQTNKQ SVSK 684
Length:684
Mass (Da):77,336
Last modified:November 4, 2008 - v1
Checksum:i8254AE19456BE382
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAR66395.1.
RefSeqiXP_002770877.1. XM_002770831.1.

Genome annotation databases

GeneIDi8999041.
KEGGidha:DEHA2F22352g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382138 Genomic DNA. Translation: CAR66395.1 .
RefSeqi XP_002770877.1. XM_002770831.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.B5RUL7.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8999041.
KEGGi dha:DEHA2F22352g.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi CERAINI.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKEX1_DEBHA
AccessioniPrimary (citable) accession number: B5RUL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 4, 2008
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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